FURTHER-STUDIES ON THE COMPOSITION OF HUMAN FEMORAL-HEAD CARTILAGE
FURTHER-STUDIES ON THE COMPOSITION OF HUMAN FEMORAL-HEAD CARTILAGE
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DOI：
10.1136/ard.39.5.514
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发表时间：
1980-01-01
影响因子：
27.4
通讯作者：
VENN, MF
中科院分区：
文献类型：
--
作者：
MAROUDAS, A;BAYLISS, MT;VENN, MF
本报告延续了我们以前对关节软骨成分和肿胀的研究。当考虑蛋白聚糖部分的蛋白质部分时，不再有大部分组织未被考虑。事实上，胶原蛋白、蛋白多糖和游离电解质占成人股骨头软骨干重的92%以上，其余的很可能由其他糖蛋白组成。一旦软骨的组成被明确定义，就可以计算正常和骨关节炎软骨每单位重量胶原蛋白的组织总湿体积。这是一个重要的参数，因为它构成了胶原蛋白网络可延展性的直接测量。通过确定靠近关节面的固定电荷密度分布，我们也能够估计由于该组织区域中的蛋白聚糖引起的膨胀压力，并表明渗透应力有一个温和的分级。
This report continues our previous studies on the composition and swelling of articular cartilage. When the protein part of the proteoglycan moiety has been taken into consideration, there is no longer a large fraction of the tissue which is not accounted for. In fact, the collagen, proteoglycans, and free electrolyte represent over 92% of the dry weight of adult femoral head cartilage, the remainder consisting most probably of other glycoproteins. Once the composition of cartilage had been well defined, it was possible to calculate the overall wet volume of tissue per unit weight of collagen for both normal and osteoarthritic cartilage. This is an important parameter, as it constitutes a direct measure of the extensibility of the collagen network. By determining the fixed charge density profile close to the articular surface, we have also been able to estimate the swelling pressure due to the proteoglycans in this region of the tissue, and to show that there is a gentle grading of osmotic stresses.