The HSSP database of protein structure-sequence alignments
The HSSP database of protein structure-sequence alignments
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DOI：
10.1093/nar/25.1.226
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发表时间：
1997-01-01
影响因子：
14.9
通讯作者：
Sander, C
中科院分区：
文献类型：
--
作者：
Schneider, R;deDaruvar, A;Sander, C
HSSP是一个衍生的数据库合并结构（3-D）和序列（1-D）信息。对于来自蛋白质数据库（PDB）的已知3-D结构的每个蛋白质，数据库具有所有可用同源物的多序列比对和家族特征的序列谱。同源物列表是使用用于序列概况比对的位置加权动态编程方法（MaxHom）在SwissProt中进行数据库搜索的结果。数据库经常更新。列出的同源物很可能具有与它们所比对的PDB蛋白相同的3-D结构。因此，该数据库不仅是比对序列家族的数据库，而且是隐含的二级和三级结构的数据库，覆盖了所有SwissProt-stored序列的29%。
HSSP is a derived database merging structural (3-D) and sequence (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in SwissProt using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 29% of all SwissProt-stored sequences.