An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections.
An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections.
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DOI：
10.3389/fcimb.2017.00162
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发表时间：
2017
影响因子：
5.7
通讯作者：
Hadjifrangiskou M
中科院分区：
文献类型：
--
作者：
Breland EJ;Eberly AR;Hadjifrangiskou M
肠道外致病性大肠杆菌感染在哺乳动物和鸟类中很常见。主要的大肠杆菌类型是禽致病性大肠杆菌（APEC）、引起新生儿脑膜炎的大肠杆菌/脑膜炎相关大肠杆菌（NMEC/MAEC）和尿路致病性大肠杆菌（UPEC）。许多综述已经描述了目前关于exp感染策略和毒力因素的知识，特别是对于upc。然而，令人惊讶的是，关于在expc发病机制中被确定为关键的调控模块的报道很少。双组分系统（TCSs）是细菌应对环境变化的主要方法，并在调节不同生态位的细菌适应性方面发挥重要作用。最近的研究强调了操纵信号转导系统作为化学重新连接细菌病原体的手段的潜力，从而减少选择压力并避免抗生素耐药性的出现。本综述首先简要介绍了APEC、NMEC和UPEC的特征感染策略和常见毒力因子，然后全面概述了影响ExPEC发病机制的双组分信号转导网络。
Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds. The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis causing E. coli/meningitis associated E. coli (NMEC/MAEC), and uropathogenic E. coli (UPEC). Many reviews have described current knowledge on ExPEC infection strategies and virulence factors, especially for UPEC. However, surprisingly little has been reported on the regulatory modules that have been identified as critical in ExPEC pathogenesis. Two-component systems (TCSs) comprise the predominant method by which bacteria respond to changing environments and play significant roles in modulating bacterial fitness in diverse niches. Recent studies have highlighted the potential of manipulating signal transduction systems as a means to chemically re-wire bacterial pathogens, thereby reducing selective pressure and avoiding the emergence of antibiotic resistance. This review begins by providing a brief introduction to characterized infection strategies and common virulence factors among APEC, NMEC, and UPEC and continues with a comprehensive overview of two-component signal transduction networks that have been shown to influence ExPEC pathogenesis.