EFFECTS OF RECOMBINANT INSULIN-LIKE GROWTH FACTOR-I ON INSULIN-SECRETION AND RENAL-FUNCTION IN NORMAL HUMAN-SUBJECTS
EFFECTS OF RECOMBINANT INSULIN-LIKE GROWTH FACTOR-I ON INSULIN-SECRETION AND RENAL-FUNCTION IN NORMAL HUMAN-SUBJECTS
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DOI：
10.1073/pnas.86.8.2868
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发表时间：
1989-04-01
影响因子：
11.1
通讯作者：
FROESCH, ER
中科院分区：
文献类型：
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作者：
GULER, HP;SCHMID, C;FROESCH, ER
胰岛素样生长因子I（IGF-I）是生长激素（GH）作用的重要介质，评估其可能的临床应用似乎很有吸引力。将重组IGF-I皮下输注。以20 μ g/kg体重/小时的剂量在两名健康成年受试者中持续6天。血糖和空腹胰岛素水平保持在正常范围内，IGF-II水平受到抑制。与胰岛素相比，空腹C肽水平降低。GH分泌也被IGF-I抑制。我们的初步数据使我们能够区分生长激素本身和IGF-I的影响：生长激素导致高胰岛素血症，而IGF-I导致胰岛素分泌减少。在IGF-I输注期间，通过肌酐清除率估计的肾小球滤过率增加至输注前值的130%。总肌酐和尿素排泄量保持不变。我们得出结论，IGF-I影响肾功能，与GH相反，发挥胰岛素节约作用。可以推测IGF-I的治疗谱与GH的治疗谱有很大不同。
Insulin-like growth factor I (IGF-I) is an important mediator of growth hormone (GH) action and it appeared tempting to evaluate possible clinical applications. Recombinant IGF-I was infused s.c. at a dose of 20 .mu.g/kg of body weight per hour during 6 days in two healthy adult subjects. Blood glucose and fasting insulin levels remained within normal limits and IGF-II levels were suppressed. In contrast to insulin, fasting C peptide levels were decreased. GH secretion was also suppressed by IGF-I. Our preliminary data allow us to distinguish between the effects of GH per se and those of IGF-I: GH causes hyperinsulinism, whereas IGF-I leads to decreased insulin secretion. Glomerular filtration rate, as estimated by creatinine clearance, increased to 130% of preinfusion values during the IGF-I infusion. Total creatinine and urea excretion remained unchanged. We conclude that IGF-I influences kidney function and, in contrast to GH, exerts an insulin-sparing effect. It may be speculated that the therapeutic spectrum of IGF-I is quite different from that of GH.