Correction: Effect of selective oxidation of bacterial cellulose on degradability in phosphate buffer solution and their affinity for epidermal cell attachment
Correction: Effect of selective oxidation of bacterial cellulose on degradability in phosphate buffer solution and their affinity for epidermal cell attachment
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DOI：
10.1039/c4ra90063d
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发表时间：
2014-11
期刊：
影响因子：
3.9
通讯作者：
Xiangning Shi;Qiuyan Cui;Yudong Zheng;Shuai Peng;Guojie Wang;Yajie Xie
中科院分区：
文献类型：
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作者：
Xiangning Shi;Qiuyan Cui;Yudong Zheng;Shuai Peng;Guojie Wang;Yajie Xie
细菌纤维素（BC）由于其三维纳米网络和良好的生物相容性，在生物医学工程中具有非常有前景的应用。然而，BC在没有纤维素酶的情况下很难在体内降解，这限制了其潜在的应用。本工作采用NO2气体选择性氧化的方法制备了氧化细菌纤维素(OBC)。通过 FTIR、XRD 和 SEM 对 OBC 的结构和微观形貌进行了表征。结果表明，氧化并未破坏BC的晶体结构或改变其结晶度。 OBC仍然保持3D纳米原纤维网络，而OBC纳米原纤维网络中每根纤维的直径变得更宽。当浸泡在PBS中时，OBC逐渐降解，降解60天后OBC的质量损失率和降解率均远高于BC。降解从表面到内部发生，网络的氧化部分有利于该过程。细胞粘附和增殖研究的结果还表明，OBC 具有与 BC 相似的优异的细胞亲和力。
Bacterial cellulose (BC) has a very promising application in biomedical engineering due to its three dimensional nano-network and good biocompatibility. However, it is difficult for BC to degrade in vivo without cellulase, which has limited its potential application. In this work, oxidized bacterial cellulose (OBC) was prepared according to selective oxidation with NO2 gas. The structure and micromorphology of OBC were characterized by FTIR, XRD, and SEM. The results showed that the oxidation did not break the crystal structure or alter the crystallinity of BC. OBC still maintained the 3D nano-fibrils network, whereas the diameter of each fiber in the nano-fibrils network of OBC became wider. When immersed in PBS, OBC degraded gradually, and the mass loss rate and degradation rate of OBC were much higher than those of BC after degradation for 60 days. Degradation occurred from surface to inside and the oxidized part of the network favored the process. Results of cell adhesion and proliferation studies also revealed that OBC had excellent cellular affinity similar to BC.