The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation
The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation
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DOI：
10.2217/epi-2018-0042
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发表时间：
2018-11-01
期刊：
影响因子：
3.8
通讯作者：
Boyce, W. Thomas
中科院分区：
文献类型：
--
作者：
Bush, Nicole R.;Edgar, Rachel D.;Boyce, W. Thomas
Aim: To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. Materials & methods: In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. Results: Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. Conclusion: Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.
