Weekend Ecstasy use disrupts memory in rats.
Weekend Ecstasy use disrupts memory in rats.
复制标题
周末使用摇头丸会扰乱老鼠的记忆。
DOI：
10.1016/j.neulet.2013.05.030
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发表时间：
2013
影响因子：
2.5
通讯作者：
Duvauchelle,ChristineL
中科院分区：
文献类型：
--
作者：
McAleer,LeahM;Schallert,Timothy;Duvauchelle,ChristineL
3,4-Methylenedioxymethamphetamine (MDMA, or “Ecstasy”) is a popular recreational drug. However, its exposure is often limited to the weekends in a highly stimulating environment. The goal of this study was to investigate the behavioral domains of working and recognition memory within a model of “weekend” Ecstasy use. Rats self-administered MDMA during 2-h sessions on two consecutive days followed by five drug-free days. Coupling this intermittent dosing schedule with a novel object recognition task, we found non-spatial memory impaired after only two “weekends” of self-administered MDMA. Our findings suggest that MDMA at recreational use levels can disrupt memory processes.
