New means of canine leishmaniasis transmission in north america: the possibility of transmission to humans still unknown.
New means of canine leishmaniasis transmission in north america: the possibility of transmission to humans still unknown.
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DOI：
10.1155/2009/802712
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发表时间：
2009
影响因子：
--
通讯作者：
Petersen CA
中科院分区：
文献类型：
--
作者：
Petersen CA
目前还不可能提前确定婴儿利什曼原虫感染的结局。犬内脏利什曼病（VL），由Le。婴儿期是一个自然的疾病过程，它提供了一个深入了解宿主和由此产生的疾病结果的相互作用。犬VL导致与人类相同的病理生理学改变和免疫失调。美国犬的VL可能主要通过非传统的非媒介方式传播。VL由Le介导。婴儿感染是美国猎狐犬的地方病，垂直传播可能是新的主要传播方式。这群狗提供了一个机会，以确定自然疾病的宿主因素。只有更好地了解主要储存宿主（狗）的疾病生态，才能预防人类临床内脏利什曼病。
At present it is not possible to determine in advance the outcome of Leishmania infantum infection. Canine Visceral Leishmaniasis (VL), caused by Le. infantum, is a natural disease process which offers a insight into the interaction of the host and resultant disease outcome. Canine VL results in the same altered pathophysiology and immunodysregulation seen in humans. VL in US dogs is likely to be transmitted primarily via nontraditional, nonvector means. VL mediated by Le. infantum is endemic in U.S. Foxhound dogs, with vertical transmission likely to be the novel primary means of transmission. This population of dogs offers an opportunity to identify host factors of natural disease. Prevention of human clinical visceral leishmaniasis can occur only by better understanding the disease ecology of the primary reservoir host: the dog.