Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water.
Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water.
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DOI：
10.1021/acs.langmuir.6b00637
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
S. Ohno;K. Ishihara;S. Yusa
中科院分区：
文献类型：
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作者：
S. Ohno;K. Ishihara;S. Yusa
采用自由基聚合法合成了2-（丙烯酰胺基）-2-甲基丙磺酸钠（AMPS）和11-甲基丙烯酰胺基十一烷酸钠（MaU）的无规共聚物（p（A/MaU）），该共聚物在酸性条件下由于十一烷酸侧基之间的分子内疏水相互作用而形成单聚体胶束。在碱性条件下，单聚物胶束通过侧链磺酸根和十一烷酸根阴离子之间的静电排斥打开为扩展的链构象。采用可控自由基聚合法合成了由聚（3-（甲基丙烯酰胺基）丙基）三甲基氯化铵（PMAPTAC）和亲水性聚甜菜碱（2-（甲基丙烯酰氧基）乙基磷酰胆碱（MPC））组成的阳离子二嵌段共聚物（P163 M99）。混合p（A/MaU）和P163 M99在0.1 M NaCl水溶液中在酸性条件下导致形成的球形聚离子复合物（PIC）胶束和囊泡，这取决于混合前的聚合物浓度。由于p（A/MaU）和P163 M99之间的电荷平衡崩溃，PIC胶束和囊泡的pH值在碱性条件下发生变化。PIC囊泡可以包含非离子亲水性客体分子，并且PIC胶束和囊泡可以在由p（A/MaU）形成的疏水核中接受疏水性客体分子。
A random copolymer (p(A/MaU)) of sodium 2-(acrylamido)-2-methylpropanesulfonate (AMPS) and sodium 11-methacrylamidoundecanate (MaU) was prepared via conventional radical polymerization, which formed a unimer micelle under acidic conditions due to intramolecular hydrophobic interactions between the pendant undecanoic acid groups. Under basic conditions, unimer micelles were opened up to an expanded chain conformation by electrostatic repulsion between the pendant sulfonate and undecanoate anions. A cationic diblock copolymer (P163M99) consisting of poly(3-(methacrylamido)propyl)trimethylammonium chloride (PMAPTAC) and hydrophilic polybetaine, 2-(methacryloyloxy)ethylphosphorylcholine (MPC), blocks was prepared via controlled radical polymerization. Mixing of p(A/MaU) and P163M99 in 0.1 M aqueous NaCl under acidic conditions resulted in the formation of spherical polyion complex (PIC) micelles and vesicles, depending on polymer concentration before mixing. Shapes of the PIC micelles and vesicles changed under basic conditions due to collapse of the charge balance between p(A/MaU) and P163M99. The PIC vesicles can incorporate nonionic hydrophilic guest molecules, and the PIC micelles and vesicles can accept hydrophobic guest molecules in the hydrophobic core formed from p(A/MaU).