Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
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DOI：
10.1164/rccm.200808-1361oc
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发表时间：
2009-05-01
影响因子：
24.7
通讯作者：
Litonjua, Augusto A.
中科院分区：
文献类型：
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作者：
Brehm, John M.;Celedon, Juan C.;Litonjua, Augusto A.
理由：怀孕期间母亲维生素 D 的摄入量与儿童早期的哮喘症状呈负相关。然而，尚无研究检验测量的维生素 D 水平与儿童期哮喘严重程度标志物之间的关系。 目的：确定测量的维生素 D 水平与儿童期哮喘严重程度和过敏标志物之间的关系。 方法：我们在一项对 616 名 6 至 14 岁哥斯达黎加儿童进行的横断面研究中，研究了 25-羟基维生素 D 水平（维生素 D 的主要循环形式）与过敏和哮喘严重程度标志物之间的关系。线性、逻辑回归和负二项回归用于单变量和多变量分析。测量和主要结果 - 在 616 名哮喘儿童中，175 名 (28%) 的维生素 D 水平不足（
Rationale: Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood.Objectives: To determine the relationship between measured vitamin D levels and both markers of asthma severity and allergy in childhood.Methods: We examined the relation between 25-hydroxyvitamin D levels (the major circulating form of vitamin D) and markers of allergy and asthma severity in a cross-sectional study of 616 Costa Rican children between the ages of 6 and 14 years. Linear, logistic, and negative binomial regressions were used for the univariate and multivariate analyses.Measurements and Main Results- Of the 616 children with asthma, 175 (28%) had insufficient levels of vitamin D (