Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction
Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction
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DOI：
10.1002/lsm.23011
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发表时间：
2019-02-01
影响因子：
2.4
通讯作者：
Iosifescu, Dan, V
中科院分区：
文献类型：
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作者：
Cassano, Paolo;Dording, Christina;Iosifescu, Dan, V
目的经颅光生物调节（Transcranial photobiomodulation，t-PBM）是将近红外（near-infrared，NIR）光或红光照射到头皮，使其穿透大脑下皮层的一种生物学效应。近红外t-PBM最近已成为一种潜在的治疗脑疾病。本研究评估了重复NIR t-PBM治疗对性功能障碍的疗效。方法对t-PBM治疗重性抑郁症（MDD）的双盲临床试验进行二次分析。20名个体接受NIR t-PBM（n = 9）或假治疗（n = 11），每周两次，持续8周。性欲、性唤起和性高潮采用治疗后出现的性高潮特异性询问系统评估（SAFTEE-SI）进行评估。结果治疗后性功能平均改善在整个样本中，在NIR模式下接受t-PBM的受试者中，SAFTEE性别总评分的降低显著大于接受假手术模式的受试者（NIR [n = 9] -2.55 +/- 1.88 vs.假手术[n = 11] -0.45 +/- 1.21; z = 2.548，P = 0.011]）和完成者（NIR [n = 5] -3.4 +/- 1.95 vs. sham [n = 7] -0.14 +/- 1.21; z = 2.576，P = 0.010]）。结论小样本的探索性研究表明，重复的近红外t-PBM治疗可能与性功能障碍的治疗效果有关。在我们的队列中，后者似乎与t-PBM的抗抑郁作用无关。激光外科医学51：127-135，2019。(c)2018 Wiley Periodicals，Inc.
Objectives Transcranial photobiomodulation (t-PBM) consists of the delivery of near-infrared (NIR) or red light to the scalp designed to penetrate to subjacent cortical areas of the brain. NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t-PBM on sexual dysfunction. Methods We performed a secondary analysis of a double-blind clinical trial on t-PBM for major depressive disorder (MDD). Twenty individuals received NIR t-PBM (n = 9) or sham therapy (n = 11) twice a week for 8 weeks. Sexual desire, arousal, and orgasm were assessed using the Systematic Assessment for Treatment-Emergent Effects-Specific Inquiry (SAFTEE-SI). Results The mean improvement in sexual function (decrease in SAFTEE sex total score) in subjects receiving t-PBM in NIR-mode was significantly greater than in subjects receiving sham-mode in the whole sample (NIR [n = 9] -2.55 +/- 1.88 vs. sham [n = 11] -0.45 +/- 1.21; z = 2.548, P = 0.011]) and in the completers (NIR [n = 5] -3.4 +/- 1.95 vs. sham [n = 7] -0.14 +/- 1.21; z = 2.576, P = 0.010]). Conclusion This exploratory study with a small sample size indicates that repeated sessions of NIR t-PBM may be associated with therapeutic effects on sexual dysfunction. The latter appeared unrelated to the antidepressant effect of t-PBM in our cohort. Lasers Surg. Med. 51:127-135, 2019. (c) 2018 Wiley Periodicals, Inc.