Histologic criteria for diagnosing primary cutaneous malignant melanoma
Histologic criteria for diagnosing primary cutaneous malignant melanoma
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DOI：
10.1038/modpathol.3800508
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发表时间：
2006-02-01
期刊：
影响因子：
7.5
通讯作者：
Smoller, BR
中科院分区：
文献类型：
--
作者：
Smoller, BR
恶性黑色素瘤在皮肤癌死亡人数中所占比例最大。它还为组织病理学家提供了最大的诊断挑战。本文试图描述与最常见黑色素瘤亚型的各种生长模式最密切相关的组织学特征。虽然已经多次表明组织学亚型可能为临床医生和患者提供很少甚至没有预后信息，但将这些实体分开以阐明黑色素瘤类肿瘤中所见的各种组织学特征是有用的。讨论围绕在显微镜下观察到的与该诊断相关的变化清单展开。本章的目的是为读者提供关于用于建立（或排除）黑色素瘤诊断的一系列变化的观点。有一篇全面的文献批判性地评估了与这组肿瘤相关的组织学参数，并将它们与预后信息联系起来，并且不会尝试将组织学变化与预后信息相关联。这将在本卷的另一章中讨论。同样，更深奥的黑色素瘤亚型的组织学特征不同于常见类型的黑色素瘤，将在另一章中讨论。
Malignant melanoma accounts for the largest number of deaths attributed to skin cancer. It also provides the most diagnostic challenges for the histopathologist. This article, attempts to describe the histologic features most closely associated with the various growth patterns of the most common subtypes of melanoma. While it has been shown repeatedly that histologic subtypes likely provide clinicians and patients with minimal to no prognostic information, it is useful to separate these entities in order to elucidate the varied histologic features seen within the class of tumors known as melanoma. The discussion centers around a checklist of changes seen at the microscope that are associated with this diagnosis. The goal of this chapter is to provide the reader with one perspective on the series of changes that are used in order to establish (or exclude) a diagnosis of melanoma. There is a comprehensive literature that critically evaluates histologic parameters associated with this collection of tumors and relates them to prognostic information, and no attempt will be made to correlate the histologic change with prognostic information. This will be discussed in another chapter in this volume. Similarly, more esoteric subtypes of melanoma are characterized by histologic features that differ from the common types of melanoma and will be addressed in another chapter.