How to design and implement a university-based COVID-19 testing programme? An evaluation of a novel RT-LAMP COVID-19 testing programme in a UK university.
How to design and implement a university-based COVID-19 testing programme? An evaluation of a novel RT-LAMP COVID-19 testing programme in a UK university.
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DOI：
10.1186/s12913-022-08717-5
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发表时间：
2022-12-09
影响因子：
2.8
通讯作者：
Baker, Philip N. N.
中科院分区：
文献类型：
--
作者：
Blackmore, Claire;Hall, Gareth W. W.;Allsopp, Rebecca C. C.;Hansell, Anna L. L.;Cowley, Caroline M. M.;Barber, Ruth C. C.;Holmes, Christopher W. W.;Tobin, Martin D. D.;Shaw, Jacqui A. A.;Brunskill, Nigel J. J.;Baker, Philip N. N.
关于如何实施无症状检测作为控制新冠肺炎传播的方法，以及无症状感染在大学人群中的流行率，人们知之甚少。本研究的目的是探讨如何利用新的逆转录环介导的等温扩增(RT-LAMP)技术有效地建立和实施新冠肺炎检测程序，并量化大学校园内无症状感染的规模。这项观察性研究描述了2020年9月至12月期间英国一所大学校园内新型新冠肺炎测试计划的建立和实施情况。RT-LAMP检测用于识别无症状病例。在研究期间，使用RT-LAMP共进行了1,673次检测，其中9次新冠肺炎呈阳性，总阳性率为0.54%，相当于在整个检测期间被测人群中每10万人中有538例阳性。RT-PCR检测全部阳性，假阳性率为0%。这项研究表明，与当地医疗保健提供者合作，使用RT-LAMP测试，快速建立新冠肺炎的通用大学测试计划是可能的。阳性结果与当地人群相似，尽管感染高峰不同。为测试方案的设计提供信息的进一步研究包括对那些接受测试的人进行重点小组，并进一步询问那些选择接受测试的人的人口统计情况，以查明潜在的准入问题或不平等。网上版载有补充材料，可在10.1186/s12913-022-08717-5查阅。
Little is known about how asymptomatic testing as a method to control transmission of COVID-19 can be implemented, and the prevalence of asymptomatic infection within university populations. The objective of this study was to investigate how to effectively set-up and implement a COVID-19 testing programme using novel reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) technology and to quantify the scale of asymptomatic infection on a university campus. An observational study to describe the set-up and implementation of a novel COVID-19 testing programme on a UK university campus between September and December 2020. RT-LAMP testing was used to identify asymptomatic cases. A total of 1,673 tests were performed using RT-LAMP during the study period, of which 9 were positive for COVID-19, giving an overall positivity rate of 0.54%, equivalent to a rate in the tested population of 538 cases per 100,000 over the duration of testing. All positive tests were found to be positive on RT-PCR testing, giving a false positive rate of 0%. This study shows that it is possible to rapidly setup a universal university testing programme for COVID-19 in collaboration with local healthcare providers using RT-LAMP testing. Positive results were comparable to those in the local population, though with a different peak of infection. Further research to inform the design of the testing programme includes focus groups of those who underwent testing and further interrogation of the demographics of those opting to be tested to identify potential access problems or inequalities. The online version contains supplementary material available at 10.1186/s12913-022-08717-5.
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影响因子：
3.1
作者：
Howson ELA;Kidd SP;Armson B;Goring A;Sawyer J;Cassar C;Cross D;Lewis T;Hockey J;Rivers S;Cawthraw S;Banyard A;Anderson P;Rahou S;Andreou M;Morant N;Clark D;Walsh C;Laxman S;Houghton R;Slater-Jefferies J;Costello P;Brown I;Cortes N;Godfrey KM;Fowler VL
通讯作者：
Fowler VL
DOI：
10.1073/pnas.2011221117
发表时间：
2020-09-29
影响因子：
11.1
作者：
Rabe BA;Cepko C
通讯作者：
Cepko C
影响因子：
3.7
作者：
Yanes-Lane M;Winters N;Fregonese F;Bastos M;Perlman-Arrow S;Campbell JR;Menzies D
通讯作者：
Menzies D
DOI：
10.1073/pnas.2008373117
发表时间：
2020-07-28
影响因子：
11.1
作者：
Moghadas, Seyed M.;Fitzpatrick, Meagan C.;Galvani, Alison P.
通讯作者：
Galvani, Alison P.
DOI：
10.1016/s2213-2600(20)30454-9
发表时间：
2020-12
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Brendish NJ;Poole S;Naidu VV;Mansbridge CT;Norton NJ;Wheeler H;Presland L;Kidd S;Cortes NJ;Borca F;Phan H;Babbage G;Visseaux B;Ewings S;Clark TW
通讯作者：
Clark TW