Linear contraction of stress fibers generates cell body rotation
Linear contraction of stress fibers generates cell body rotation
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应力纤维的线性收缩产生细胞体旋转
DOI：
10.1101/2023.01.03.522661
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
T. and Iwadate Y
中科院分区：
文献类型：
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作者：
Okimura;C.;Akiyama;S.;Nishigami;Y.;Zaitsu;R.;Sakurai;T. and Iwadate Y
鱼类表皮角化细胞具有快速修复创伤的功能，包括前部新月形的板状伪足和后部橄榄球形的细胞体。细胞体在迁移过程中像轮子一样旋转。应力纤维沿着橄榄球的接缝布置。在这里，我们表明应力纤维的线性收缩是旋转的驱动力。我们构建了一个玩具机械机器人的细胞体，包括一个软圆柱体与收缩线圈。根据其运动，预测应力纤维的收缩将使软细胞体变形，并且变形的细胞体将推压基底以产生扭矩。这一预测得到了迁移细胞中应力纤维动力学观察的证实。从这种独特的迁移机制中获得的知识有可能用于仿生软机器人的设计。
Fish epidermal keratocytes, which rapidly repair wounds, comprise a frontal crescent-shaped lamellipodium and a rear rugby-ball-shaped cell body. The cell body rotates like a wheel during migration. Stress fibers are arranged along the seams of the rugby ball. Here, we show the linear contraction of stress fibers to be the driving force for rotation. We constructed a toy mechanical robot of the cell body that consisted of a soft cylinder with a contractile coil. From its motion, it was predicted that contraction of the stress fibers would deform the soft cell body and that the deformed cell body would push against the substrate to generate torque. This prediction was confirmed by the observation of stress fiber dynamics in migrating cells. Knowledge gained from this unique migration mechanism has the potential to be used in the design of biomimetic soft robots.