The effect of diabetes and tissue depth on adipose chamber size and plantar soft tissue features.
The effect of diabetes and tissue depth on adipose chamber size and plantar soft tissue features.
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DOI：
10.1016/j.foot.2023.101989
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发表时间：
2023-09-01
期刊：
影响因子：
--
通讯作者：
Ledoux, William R
中科院分区：
文献类型：
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作者：
Brady, Lynda M;Rombokas, Eric;Ledoux, William R
背景：足底溃疡是糖尿病的严重并发症。然而，损伤引发溃疡的机制尚不清楚。足底软组织的独特结构包括隔室中的浅层和深层脂肪细胞，然而，这些隔室的大小在糖尿病或非糖尿病组织中尚未被量化。方法：利用预先训练好的U网络对糖尿病足底软组织和非糖尿病足底软组织的整个切片图像中的脂肪腔进行分割，测量脂肪腔的面积、周长、最小直径和最大直径。结果：非糖尿病患者的深房面积(26954±2428m2比14157±1153m2)、最大直径(277±13m比197±8m)和最小直径(140±6m比104±4m)和周长(405±19m比291±12m)分别增大了90%、41%、34%和39%。
BACKGROUND: Plantar ulceration is a serious complication of diabetes. However, the mechanism of injury initiating ulceration remains unclear. The unique structure of the plantar soft tissue includes superficial and deep layers of adipocytes contained in septal chambers, however, the size of these chambers has not been quantified in diabetic or non-diabetic tissue. Computer-aided methods can be leveraged to guide microstructural measurements and differences with disease status.METHODS: Adipose chambers in whole slide images of diabetic and non-diabetic plantar soft tissue were segmented with a pre-trained U-Net and area, perimeter, and minimum and maximum diameter of adipose chambers were measured. Whole slide images were classified as diabetic or non-diabetic using the Axial-DeepLab network, and the attention layer was overlaid on the input image for interpretation.RESULTS: Non-diabetic deep chambers were 90 %, 41 %, 34 %, and 39 % larger in area (26,954±2428m2 vs 14,157±1153m2), maximum (277±13m vs 197±8m) and minimum (140±6m vs 104±4m) diameter, and perimeter (405±19m vs 291±12m), respectively, than the superficial (p