What does the anatomical organization of the entorhinal cortex tell us?
What does the anatomical organization of the entorhinal cortex tell us?
复制标题
DOI：
10.1155/2008/381243
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
Witter MP
中科院分区：
文献类型：
--
作者：
Canto CB;Wouterlood FG;Witter MP
内嗅觉皮质通常被认为是海马结构的主要输入和输出结构，扮演着皮质-海马区回路的结点的角色。浅层接收会聚的皮质信息，这些信息被传递到海马体中的结构，而海马体的输出到达内嗅觉皮质的深层，后者投射回皮质。所有层中网格细胞的发现以及关于深层和表层之间相互作用的报告表明，这种相当简单化的看法可能是错误的。因此，考虑到我们最近增加的关于内嗅觉连接的知识数据库，关于内嗅觉皮质的综合方法是及时的。我们认为，内嗅皮层的各层表现出不同的功能特征，很可能不是基于显著不同的输入或输出，而是更有可能基于内在组织的差异，结合非常特定的输入集合。在这里，我们旨在总结最近的解剖学数据，支持这样一个概念，即传统的将内嗅皮层描述为海马结构的分层输入输出结构，并没有给予这一结构可能对皮质-海马网络的整体功能做出贡献的应有的信任。
The entorhinal cortex is commonly perceived as a major input and output structure of the hippocampal formation, entertaining the role of the nodal point of cortico-hippocampal circuits. Superficial layers receive convergent cortical information, which is relayed to structures in the hippocampus, and hippocampal output reaches deep layers of entorhinal cortex, that project back to the cortex. The finding of the grid cells in all layers and reports on interactions between deep and superficial layers indicate that this rather simplistic perception may be at fault. Therefore, an integrative approach on the entorhinal cortex, that takes into account recent additions to our knowledge database on entorhinal connectivity, is timely. We argue that layers in entorhinal cortex show different functional characteristics most likely not on the basis of strikingly different inputs or outputs, but much more likely on the basis of differences in intrinsic organization, combined with very specific sets of inputs. Here, we aim to summarize recent anatomical data supporting the notion that the traditional description of the entorhinal cortex as a layered input-output structure for the hippocampal formation does not give the deserved credit to what this structure might be contributing to the overall functions of cortico-hippocampal networks.