Cylindrical Splitt and Quadrupole Magnetic Field in Application to Continuous-Flow Magnetic Cell Sorting
Cylindrical Splitt and Quadrupole Magnetic Field in Application to Continuous-Flow Magnetic Cell Sorting
复制标题
圆柱形分流和四极磁场在连续流磁性细胞分选中的应用
DOI：
10.1080/10826079708005599
复制
发表时间：
1997
影响因子：
1.3
通讯作者：
J. Chalmers
中科院分区：
文献类型：
--
作者：
M. Zborowski;P. Williams;Liping Sun;L. Moore;J. Chalmers
四极磁场已被用于四极质谱和工业和采矿的干分离。我们建议将其用于生物医学和生物技术应用中的快速，连续流动细胞分选。我们开始使用分流细通道分离（SPLITT）的理论方法来研究这种分选机的性能。比较的理论结果和初步的实验数据，使用一个模型系统的人外周血淋巴细胞标记的免疫磁性胶体，使我们识别系统的最重要的参数。
The quadrupole magnetic field has been used for quadrupole mass spectroscopy and for industrial and mining dry separations. We propose to use it for rapid, continuous-flow cell sorting in biomedical and biotechnological applications. We set out to investigate the performance of such a sorter using the theoretical methods of split-flow thin channel separation (SPLITT). Comparison of theoretical results and preliminary experimental data, using a model system of human peripheral lymphocytes labeled with immunomagnetic colloid, led us to the identification of the most important parameters of the system.