DTPA-bisamide-based MR sensor agents for peroxidase imaging
DTPA-bisamide-based MR sensor agents for peroxidase imaging
复制标题
DOI：
10.1021/ol050208v
复制
发表时间：
2005-04-28
期刊：
影响因子：
5.2
通讯作者：
Bogdanov, A
中科院分区：
文献类型：
--
作者：
Querol, M;Chen, JW;Bogdanov, A
报道了两种新型DTPA双酰胺的合成及性质。这些衍生物被设计为用于磁共振成像的酶激活造影剂（CA）。这两种衍生物带有酪胺或5-羟色胺基团，可以在过氧化物酶/H2 O2对的存在下原位寡聚化，导致纵向（R1）弛豫率的净增加。
The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H2O2 pair resulting in a net increase in longitudinal (R1) relaxivity.