Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
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DOI：
10.1016/j.biopsych.2007.04.026
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发表时间：
2008-01-15
影响因子：
10.6
通讯作者：
Laucht, Manfred
中科院分区：
文献类型：
--
作者：
Blomeyer, Dorothea;Treutlein, Jens;Laucht, Manfred
工作背景：最近的动物研究表明，促肾上腺皮质激素释放激素受体1（CRHR 1）的改变可能导致反复应激后大量饮酒。本研究的目的是探讨两个单倍型标记的单核苷酸多态性（SNP）之间的相互作用，包括CRHR 1基因和不良生活事件大量drinking inadolescents.Methods：数据可从曼海姆研究的儿童处于危险之中，一个正在进行的队列研究的长期结果的早期危险因素，自出生以来。在15岁时，280名参与者（135名男性，145名女性）完成了测量酒精使用的自我报告问卷，并对CRHR1的两个SNP（rs242938，rs1876831）进行了基因分型。负性生活事件的评估，在过去的三年中，获得了一个标准化的采访与parents.Results：青少年纯合子的C等位基因的rs1876831喝了更高的最大量的酒精每一次，并有更大的终身率的大量饮酒的负性生活事件比携带T等位基因的个人。没有发现基因X环境的相互作用，经常饮酒和rs242938和紧张的生活events.Conclusions之间：这些研究结果提供了第一个证据表明，在人类CRHR1基因相互作用与暴露于紧张的生活事件，以预测大量使用酒精的青少年。
Background: Recent animal research suggests that alterations in the corticotropin releasing hormone receptor 1 (CRHR1) may lead to heavy alcohol use following repeated stress. The aim of this study was to examine interactions between two haplotype-tagging single nucleotide polymorphisms (SNPs) covering the CRHR1 gene and adverse life events on heavy drinking in adolescents.Methods: Data were available from the Mannheim Study of Children at Risk, an ongoing cohort study of the long-term outcome of early risk factors followed since birth. At age 15 years, 280 participants (135 males, 145 females) completed a self-report questionnaire measuring alcohol use and were genotyped for two SNPs (rs242938, rs1876831) of CRHR1. Assessment of negative life events over the past three years was obtained by a standardized interview with the parents.Results: Adolescents homozygous for the C allele of rs1876831 drank higher maximum amounts of alcohol per occasion and had greater lifetime rates of heavy drinking in relation to negative life events than individuals carrying the T allele. No gene X environment interactions were found for regular drinking and between rs242938 and stressful life events.Conclusions: These findings provide first evidence in humans that the CRHR1 gene interacts with exposure to stressful life events to predict heavy alcohol use in adolescents.