Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease.
Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease.
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慢性阻塞性肺疾病细菌定植的诱发因素。
DOI：
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发表时间：
1999
影响因子：
24.3
通讯作者：
J. Llorente
中科院分区：
文献类型：
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作者：
R. Zalacaín;V. Sobradillo;J. Amilibia;J. Barrón;V. Achótegui;J. Pijoan;J. Llorente
这项前瞻性观察性研究的目的是确定影响稳定期慢性阻塞性肺疾病（COPD）患者细菌定植的因素。88例稳定期COPD门诊患者和20例肺功能测定和胸部X线检查正常的患者（对照组）在局部气雾剂麻醉下进行了纤维支气管镜检查。使用受保护的标本刷（PSB）测定细菌定植，临界值≥ 10（3）个菌落形成单位（CFU x mL（-1））。通过单变量和多变量分析评估了年龄、气流阻塞程度、吸烟习惯、吸烟包年数和胸部X线检查结果对细菌定植的影响。在40%的患者中发现了显著的细菌生长，而在对照组中没有发现。流感嗜血杆菌、草绿色链球菌、S.肺炎和卡他莫拉菌是最常见的病原体。调整其他变量后，严重气流受限（比值比（OR）5.11，95%置信区间（CI）1.45-17.9）和当前吸烟（OR 3.17，95% CI 2.5-8）仍与细菌培养阳性相关。当仅考虑潜在致病微生物时，在30.7%的患者中发现显著的细菌生长，严重气流阻塞（OR 9.28，95% CI 2.19-39.3）是与阳性细菌培养物独立相关的唯一变量。我们的研究结果表明，稳定期慢性阻塞性肺疾病患者远端气道细菌定植的患病率较高，这主要与气流阻塞程度和吸烟有关。
The aim of this prospective observational study was to determine those factors influencing bacterial colonization in patients with stable chronic obstructive pulmonary disease (COPD). Eighty-eight outpatients with stable COPD and 20 patients with normal spirometry and chest radiography (controls) had a fibreoptic bronchoscopy performed with topical aerosol anaesthesia. Bacterial colonization was determined using the protected specimen brush (PSB) with a cut-off > or = 10(3) colony-forming units (CFU x mL(-1)). The influence of age, degree of airflow obstruction, smoking habit, pack-yrs of smoking, and chest radiographic findings on bacterial colonization were assessed by univariate and multivariate analysis. Significant bacterial growth was found in 40% of patients and in none of the controls. Haemophilus influenzae, Streptococcus viridans, S. pneumoniae and Moraxella catarrhalis were the most frequent pathogens. After adjustment for other variables, severe airflow limitation (odds ratio (OR) 5.11, 95% confidence interval (CI) 1.45-17.9) and current smoking (OR 3.17, 95% CI 2.5-8) remained associated with positive bacterial cultures. When only potentially pathogenic micro-organisms were considered, significant bacterial growth was found in 30.7% of patients, with severe airflow obstruction (OR 9.28, 95% CI 2.19-39.3) being the only variable independently associated with positive bacterial cultures. Our results show that stable chronic obstructive pulmonary disease patients have a high prevalence of bacterial colonization of distal airways which is mainly related to the degree of airflow obstruction and cigarette smoking.
慢性支气管炎急性发作的抗生素治疗。
影响因子：
39.2
作者：
Nicotra,MB;Rivera,M;Awe,RJ
通讯作者：
Awe,RJ