Nonhomogeneous deformation in the anterior leaflet of the mitral valve
Nonhomogeneous deformation in the anterior leaflet of the mitral valve
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DOI：
10.1007/s10439-004-7813-6
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发表时间：
2004-12-01
影响因子：
3.8
通讯作者：
May-Newman, K
中科院分区：
文献类型：
--
作者：
Chen, L;McCulloch, AD;May-Newman, K
在二尖瓣中，结构和材料特性的区域差异共同影响整个瓣膜的生物力学。以前的双轴试验表明，二尖瓣叶组织具有高度的延展性，并表现出非线性、各向异性的材料特性。在本研究中，在猪心上进行了准静态压力载荷下二尖瓣叶变形的实验测量。利用放置在叶前表面的标志物的双平面视频图像，在生理范围内的几个压力水平下重建标志物的三维位置。使用最小二乘有限元方法将参数模型拟合到标记上，并计算表面上的变形。结果表明，小叶的变形是各向异性的，表现为大的非均匀径向拉伸和小的周向拉伸。这些信息可以用来更好地了解瓣膜在生理负荷下的变形情况，并帮助设计瓣膜问题的治疗方案，如二尖瓣返流。
In the mitral valve, regional variations in structure and material properties combine to affect the biomechanics of the entire valve. Previous biaxial testing has shown that mitral valve leaflet tissue is highly extensible, and exhibits nonlinear, anisotropic material properties. In this study, experimental measurements of mitral valve leaflet deformation under quasi-static pressure loading were performed on isolated porcine hearts. Biplane video images of markers placed on the anterior leaflet surface were used to reconstruct the 3D position of the markers at several pressure levels over the physiological range. A least-squares finite-element method was used to fit parametric models to the markers and to calculate the deformation over the surface. The results showed that the leaflet deformations were anisotropic, exhibiting a large nonhomogeneous radial stretch and a small circumferential stretch. This information can be used to better understand how the valve deforms under physiological loading, and to help design treatments for valve problems, such as mitral regurgitation.