Clinical and EEG phenotypes of epilepsy in the baboon (Papio hamadryas spp.)
Clinical and EEG phenotypes of epilepsy in the baboon (Papio hamadryas spp.)
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DOI：
10.1016/j.eplepsyres.2005.05.003
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发表时间：
2005-06-01
影响因子：
2.2
通讯作者：
Williams, JT
中科院分区：
文献类型：
--
作者：
Szabó, CA;Leland, MM;Williams, JT
在西南生物医学研究基金会（SFBR）的几个狒狒亚种中报告了自发性癫痫发作，包括Papio hamadryas anubis以及cynocephalus/anubis和其他杂交种。本研究根据发作间期和发作期的发现以及头皮EEG的光敏性对这些亚种的临床和脑电图（EEG）表型进行分类。100只狒狒进行了1小时脑电图研究与光刺激（PS），49与以前目睹的癫痫发作和51没有。根据这些电临床表型对动物进行分类：是否存在发作间期癫痫放电（IED）、癫痫发作和光阵发性或光惊厥反应。年龄、性别和物种对EEG表型的影响也进行了研究。六个离散的电临床表型进行了鉴定。在67只狒狒中确定了2-3、4-6和/或6-7 Hz的广义IED。在40只动物中记录了癫痫发作，包括肌阵挛性和全身强直阵挛性发作。33只动物具有光敏性。尽管癫痫发作和无症状动物中IED和癫痫发作的患病率相似，但癫痫发作动物中光敏性更普遍（P = 0.001）。Rh. anubis/cynocephalus杂种比P. h. anubis（p = 0.004）。在这个家系群体中，不同癫痫表型的可靠表征对于未来遗传分析的成功至关重要，以确定其癫痫的遗传因素。(c)2005 Elsevier B. V.保留所有权利。
Spontaneous seizures have been reported in several baboon subspecies housed at the Southwest Foundation for Biomedical Research (SFBR), including Papio hamadryas anubis as well as cynocephalus/anubis and other hybrids. This study classified clinical and electroencephalographic (EEG) phenotypes in these subspecies based upon interictal and ictal findings, as well as photosensitivity, by scalp EEG. One hundred baboons underwent 1-h EEG studies with photic stimulation (PS), 49 with previously witnessed seizures and 51 without. The animals were classified according to these electroclinical phenotypes: presence or absence of interictal epileptic discharges (IEDs), seizures and photoparoxysmal or photoconvulsive responses. Effects of age, gender, and species on EEG phenotypes were also examined. Six discrete electroclinical phenotypes were identified. Generalized IEDs of 2-3, 4-6, and/or 6-7 Hz were identified in 67 baboons. Epileptic seizures were recorded in 40 animals, including myoclonic and generalized tonic-clonic seizures. Thirty-three animals were photosensitive. Although the prevalence of IEDs and seizures were similar in seizure and asymptomatic animals, photosensitivity was more prevalent in the seizure animals (P = 0.001). Rh. anubis/cynocephalus hybrids were more likely to be photosensitive than P.h. anubis (p = 0.004). The reliable characterization of distinct epileptic phenotypes in this pedigreed colony is critical to the success of future genetic analyses to identify genetic factors underlying their epilepsy. (c) 2005 Elsevier B.V. All rights reserved.