Early growth response genes regulate B cell development, proliferation, and immune response.
Early growth response genes regulate B cell development, proliferation, and immune response.
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DOI：
10.4049/jimmunol.181.7.4590
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发表时间：
2008-10-01
期刊：
影响因子：
--
通讯作者：
Bondada S
中科院分区：
文献类型：
--
作者：
Gururajan M;Simmons A;Dasu T;Spear BT;Calulot C;Robertson DA;Wiest DL;Monroe JG;Bondada S
Egr-1 (Early growth response gene-1) is an immediate early gene encoding a zinc finger motif containing transcription factor. Upon cross-linking of B cell receptor (BCR), mature B cells undergo proliferation with an increase in Egr-1. Immature B lymphoma cells that express Egr-1 constitutively are growth inhibited when Egr-1 is downregulated by negative signals from BCR or by antisense oligonucelotides. To test the hypothesis that Egr-1 is important for B-cell development, we examined B cells from primary and secondary lymphoid organs in Egr-1-/- mice. Marginal zone B cell development was arrested in these mice while the B cells in all other compartments were increased. To test the hypothesis that Egr-1 function may be partially compensated by other Egr family members, we developed transgenic mice expressing a dominant negative form of Egr-1, which lacks the transactivation domain but retains the DNA binding domain, in a B cell specific manner. There was a decrease in B lymphopioesis in the bone marrow accompanied by a reduction in splenic immature and mature B cells as well as marginal zone B cells in the transgenic mice. Moreover, transgenic mice respond poorly to BCR cross-linking in vitro and T-independent and T-dependent antigens in vivo.
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转录因子早期生长响应1（EGR-1）的进步pre-B和未成熟B细胞的分化。
DOI：
10.1084/jem.188.12.2215
发表时间：
1998-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dinkel A;Warnatz K;Ledermann B;Rolink A;Zipfel PF;Bürki K;Eibel H
通讯作者：
Eibel H
影响因子：
20.3
作者：
Gururajan, M;Chui, R;Bondada, S
通讯作者：
Bondada, S
影响因子：
4.4
作者：
Bettini, M;Xi, HK;Kersh, GJ
通讯作者：
Kersh, GJ
影响因子：
20.3
作者：
Krishnaraju, K;Hoffman, B;Liebermann, DA
通讯作者：
Liebermann, DA
影响因子：
4.4
作者：
Carleton, M;Haks, MC;Wiest, DL
通讯作者：
Wiest, DL