Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors
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DOI：
10.1016/j.virol.2004.02.016
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发表时间：
2004-05-01
期刊：
影响因子：
3.7
通讯作者：
Curiel, DT
中科院分区：
文献类型：
--
作者：
Short, JJ;Pereboev, AV;Curiel, DT
大多数病毒在成功执行感染的情况下利用多种宿主细胞蛋白作为主要细胞附着受体。此外，许多病毒制剂已经进化出精确的机制来破坏宿主的免疫识别以实现持久性。在此，我们提供的数据表明腺病毒 (Ad) 血清型 3 利用 CD80 (B7.1) 和 CD86 (B7.2) 作为细胞附着受体。 CD80 和 CD86 是存在于成熟树突细胞和 B 淋巴细胞上的共刺激分子，参与刺激 T 淋巴细胞活化。据我们所知，这是病毒利用免疫辅助分子作为进入细胞的主要手段的首次演示之一。这一发现表明病毒利用这些蛋白质作为受体可以实现进入细胞和逃避免疫系统的目标。 (C) 2004 Elsevier Inc. 保留所有权利。
Most viruses exploit a variety of host cellular proteins as primary cellular attachment receptors in the context of successful execution of infection. Furthermore, many viral agents have evolved precise mechanisms to subvert host immune recognition to achieve persistence. Herein we present data indicating that adenovirus (Ad) serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. CD80 and CD86 are co-stimulatory molecules that are present on mature dendritic cells and B lymphocytes and are involved in stimulating T-lymphocyte activation. To our knowledge, this is one of the first demonstrations of a virus utilizing immunologic accessory molecules as a primary means of cellular entry. This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system. (C) 2004 Elsevier Inc. All rights reserved.