Common scale-invariant patterns of sleep-wake transitions across mammalian species
Common scale-invariant patterns of sleep-wake transitions across mammalian species
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DOI：
10.1073/pnas.0408242101
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发表时间：
2004-12-14
影响因子：
11.1
通讯作者：
Ivanov, PC
中科院分区：
文献类型：
--
作者：
Lo, CC;Chou, T;Ivanov, PC
虽然不同物种的哺乳动物有不同的睡眠模式，但短暂的睡眠-觉醒过渡通常在不同物种中观察到，并且似乎在整个睡眠期间随机发生。从睡眠中短暂醒来的动态模式和功能尚未得到很好的理解，它们通常被视为睡眠过程的中断（随机或病理性）。在这篇文章中，我们假设，短暂的睡眠觉醒可能反映了内源性睡眠控制机制的各个方面，因此可能会表现出某些强大的跨物种的动态模式。我们分析了小鼠、大鼠、猫和人类的睡眠记录，并比较了睡眠和觉醒持续时间的分布。对于所有四个物种，我们发现，在睡眠期间短暂的觉醒事件的持续时间表现出无标度幂律行为的指数a，保持不变的所有物种（α近似为2.2）。相反，所有四个物种的睡眠事件持续时间遵循指数分布与特征时间尺度，这在物种之间的变化与体重和代谢率。我们的研究结果表明，不同物种的短暂觉醒和睡眠持续时间具有共同的动力学特征，并可能为控制睡眠的神经回路的动力学提供见解。
Although mammals of different species have different sleep patterns, brief sleep-wake transitions commonly are observed across species and appear to occur randomly throughout the sleeping period. The dynamical patterns and functions of these brief awakenings from sleep are not well understood, and they often are viewed as disruptions (random or pathologic) of the sleep process. In this article, we hypothesize that brief awakenings from sleep may reflect aspects of the endogenous sleep control mechanism and thus may exhibit certain robust dynamical patterns across species. We analyze sleep recordings from mice, rats, cats, and humans, and we compare the distributions of sleep and wake episode durations. For all four species, we find that durations of brief wake episodes during the sleep period exhibit a scale-free power-law behaviour with an exponent a that remains the same for all species (alpha approximate to 2.2). In contrast, sleep episode durations for all four species follow exponential distributions with characteristic time scales, which change across species in relation to body mass and metabolic rate. Our findings suggest common dynamical features of brief awakenings and sleep durations across species and may provide insights into the dynamics of the neural circuits controlling sleep.