Chemotherapeutic treatment of colorectal cancer in pregnancy: case report.
Chemotherapeutic treatment of colorectal cancer in pregnancy: case report.
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DOI：
10.1186/s13256-015-0621-9
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发表时间：
2015-06-13
影响因子：
1
通讯作者：
Al-Mohaisen F
中科院分区：
文献类型：
--
作者：
Makoshi Z;Perrott C;Al-Khatani K;Al-Mohaisen F
妊娠期结肠癌并不常见。文献中只发表了少数关于妊娠期间使用化疗药物的病例报告。此类病例的报告有助于临床医生进一步调查妊娠期化疗的使用。FOLFOX-6被用于一名患有转移性结肠癌的33岁沙特孕妇，妊娠22至30周。她的癌症是在怀孕期间诊断出来的。她对化疗耐受良好，生下一足月女婴，无明显危害，2年随访检查发育正常。怀孕期间的结肠癌不容易被发现，也很难控制。有恶性肿瘤症状和体征的患者需要详细的病史和高度的临床怀疑。需要一种患者参与的多学科方法来降低治疗和母亲癌症引起的发病率和死亡率，并限制对胎儿的副作用。为了更好地了解化疗药物对后代的潜在长期副作用，需要进一步的数据和长期随访。
Colon cancer in pregnancy is uncommon. Only a small number of case reports have been published in the literature on the use of chemotherapeutic drugs during pregnancy. Reports of such cases assist clinicians in further investigating the use of chemotherapy in pregnancy. FOLFOX-6 was administered to a pregnant, 33-year-old Saudi woman with metastatic colon cancer from 22 to 30 weeks of gestation. Her cancer was diagnosed during her pregnancy. She tolerated the chemotherapy well and delivered a full-term baby girl with no obvious harm, and normal development was documented at her 2-year follow-up examination. Colon cancer during pregnancy is not easily detected and is difficult to manage. A detailed history and high clinical suspicion are needed in patients who present with symptoms and signs suggestive of malignancy. A multidisciplinary approach with patient involvement is needed to decrease morbidity and mortality caused by both treatment and the cancer in the mother and to limit side effects for the fetus. Further data and long-term follow-up are needed to better understand the potential long-term side effects of chemotherapeutic drugs on offspring.