Secondary Cancer Prevention During Follow-up for Endometrial Cancer
Secondary Cancer Prevention During Follow-up for Endometrial Cancer
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DOI：
10.1097/aog.0b013e31819c842d
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发表时间：
2009-04-01
影响因子：
7.2
通讯作者：
Grunfeld, Eva
中科院分区：
文献类型：
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作者：
Kwon, Janice S.;Elit, Laurie;Grunfeld, Eva
目的：进行一项以人群为基础的研究子宫内膜癌后继发性乳腺癌和结直肠癌的发病率和筛查率，并评估其对随访的影响。初始队列包括1996年至2000年在加拿大安大略诊断为子宫内膜癌的所有女性，既往无乳腺癌或结直肠癌病史。我们在随访期间确定了5年复发率和总生存率以及医生类型。主要结果是随访期间乳腺癌和结直肠癌的年龄标准化发病率和筛查率与一般女性人群的比较。5年复发率为15.0%，总生存率为79.3%。家庭医生最常参与后续护理。乳腺癌和结直肠癌的标准化发病率分别为0.5%和0.7%，而乳腺癌和结直肠癌的标准化发病率分别为0.5%（P= 0.76）和0.2%（P
OBJECTIVE: To conduct a population-based study of incidence and screening rates for secondary breast and colorectal cancers after endometrial cancer and to assess implications for follow-up.METHODS: This was a retrospective population-based study from administrative databases. The inception cohort included all women diagnosed with endometrial cancer in Ontario, Canada from 1996 to 2000, without a previous history of breast or colorectal cancer. We ascertained 5-year recurrence and overall survival rates and practitioner type during follow-up. Primary outcomes were age-standardized incidence and screening rates of breast and colorectal cancer during follow-up compared with the general female population.RESULTS: There were 3,473 women in the cohort. The 5-year recurrence rate was 15.0% and overall survival was 79.3%. Family physicians were most often involved in follow-up care. Age-standardized incidence rates of breast and colorectal cancer were 0.5% and 0.7%, respectively, compared with 0.5% (P=.76) and 0.2% (P