Distant metastasis of hepatocellular carcinoma after successful treatment of the primary lesion.
Distant metastasis of hepatocellular carcinoma after successful treatment of the primary lesion.
复制标题
原发灶成功治疗后肝细胞癌远处转移。
作者：
Y. Inagaki;M. Unoura;T. Urabe;H. Ogino;S. Terasaki;E. Matsushita;S. Kaneko;T. Morioka;A. Furusawa;T. Wakabayashi
肝细胞癌（HCC）诊断和治疗的最新进展改善了预后，并改变了随后增加的远处转移的临床意义。在163例HCC患者中，76例（47%）成功治疗。这些患者3年后的累积复发率为65%，5年后为82%。本文报告了6例原发灶成功治疗后发现远处转移的HCC患者。2例患者接受了根治性手术切除，4例患者接受了药物治疗，导致CT扫描图像中肿瘤大小减少了31.9%至94.3%。原发病灶治疗后10 ~ 46个月诊断为远处转移，无肝内复发。转移部位包括骨3例、肺2例和肾上腺1例。原发灶治疗成功后发现远处转移对肝癌的治疗具有重要的临床意义。
Recent advances in both diagnosis and treatment of hepatocellular carcinoma (HCC) have improved the prognosis and changed the clinical significance of the subsequently increasing distant metastases. Of 163 patients with HCC, 76 (47%) were treated successfully. The cumulative recurrence rate in these patients was 65% after 3 years, and 82% after 5 years. Six patients with HCC in whom distant metastases were detected after successful treatment of the primary lesion, are reported. Two patients underwent curative surgical resection, and four cases were treated medically, resulting in a 31.9 to 94.3% reduction in tumor size in the CT scan image. Distant metastases without intrahepatic recurrence were diagnosed 10 to 46 months after the treatment of the primary lesions. The sites of the metastases included bone 3; lung 2; and adrenal gland 1. Distant metastases found after successful treatment of the primary lesions are of great clinical significance for the treatment of HCC.