Use of a Mechanical Circulatory Support Simulation to Study Pump Interactions With the Variable Hemodynamic Environment.
Use of a Mechanical Circulatory Support Simulation to Study Pump Interactions With the Variable Hemodynamic Environment.
复制标题
使用机械循环支持模拟来研究泵与可变血流动力学环境的相互作用。
DOI：
10.1111/aor.13287
复制
发表时间：
2018
影响因子：
2.4
通讯作者：
Fukamachi,Kiyotaka
中科院分区：
文献类型：
--
作者：
Horvath,DavidJ;Horvath,DennisW;Karimov,JamshidH;Byram,Nicole;Kuban,BarryD;Miyamoto,Takuma;Fukamachi,Kiyotaka
虚拟模拟回路是一种多功能虚拟模拟循环回路，使用机械辅助人体循环系统的集总参数模型开发。输入允许指定各种连续流泵（左、右或双心室辅助装置）和可以在左和右泵输出之间进行自我调节的全人工心脏。使用基于疾病的输入面板简化血流动力学输入，允许选择心血管疾病状态的组合，包括四个瓣膜中的收缩期和舒张期心力衰竭、狭窄和/或返流，以及从高到低的全身和肺血管阻力值。菜单驱动的输出包括血液动力学参数的汇总，以及心脏四个腔室以及肺动脉和主动脉中选定流量、压力和容积的图形输出。新的工具，以加强对植入式心脏辅助设备的实验研究，并增加我们对患者特定泵相互作用的理解，需求量很大。这项正在进行的研究的目的是证明使用系统分析计算机模拟来探索和更好地理解机械循环支持泵与患者特定条件或模拟条件的更广泛组合的相互作用，而不是通过实际实验确定。可用性是构建用于研究目的的计算机模型的一个重要因素，我们创建此仿真模型的主要目标之一是使其在实验室环境之外尽可能便携和有用，由不参与创建其操作软件的人员使用。
The Virtual Mock Loop, a versatile virtual mock circulation loop, was developed using a lumped‐parameter model of the mechanically assisted human circulatory system. Inputs allow specification of a variety of continuous‐flow pumps (left, right, or biventricular assist devices) and a total artificial heart that can self‐regulate between left and right pump outputs. Hemodynamic inputs were simplified using a disease‐based input panel, allowing selection of a combination of cardiovascular disease states, including systolic and diastolic heart failure, stenosis, and/or regurgitation in each of the four valves, and high to low systemic and pulmonary vascular resistance values. The menu‐driven output includes a summary of hemodynamic parameters and graphical output of selected flows, pressures, and volumes in the heart's four chambers as well as in the pulmonary artery and aorta.New tools to augment experimental research on implantable heart‐assist devices and to increase our understanding of patient‐specific pump interactions are in high demand. The purpose of this ongoing study is to demonstrate the use of a system analysis computer simulation to explore and better comprehend the interactions of mechanical circulatory support pumps with a more extensive combination of patient‐specific or simulation conditions than can be established by practical experimentation. Usability is an important factor in constructing computer models for research purposes, and among our primary objectives in creating this simulation model were to make it as portable and useful as possible outside the lab environment, by people not involved in the creation of its operational software.