Footprints of aminoacyl-tRNA synthetases are everywhere
Footprints of aminoacyl-tRNA synthetases are everywhere
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DOI：
10.1016/s0968-0004(00)01553-x
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发表时间：
2000-05-01
影响因子：
13.8
通讯作者：
De Pouplana, LR
中科院分区：
文献类型：
--
作者：
Schimmel, P;De Pouplana, LR
图1从现有aaRS结构或其模块化前体中出现氨基酰基trna合成酶（aaRS）样蛋白的模型。现存氨基酰基- trna合成酶的类定义结构域（灰色）可能是最古老的模块，并通过添加的rna结合元件（虚线）与迷你螺旋结构域（以迷你螺旋结构为例）相互作用（参见参考文献9）。在现有的aars（红色和蓝色）中添加了额外的结构域和插入，可能是为了通过新的分子相互作用增加每种酶对其同源trna的特异性13。这个过程（用虚线箭头表示）产生了现存形式的氨基酰基- trna合成酶。在这一进化过程的任何阶段，单个结构域或它们的组合都可能发生分化（实箭头），从而产生现存的类aars蛋白质，如图右方框所示。
Figure 1 Model for the emergence of aminoacyl-tRNA synthetase (aaRS)-like proteins from extant aaRS structures or their modular precursors. The class-defining domain of extant aminoacyl-tRNA synthetases (in gray) is likely to be the oldest module and interacted with a minihelix-like domain (exemplified by a minihelix structure) through RNA-binding elements that were added (dashed lines)(see Ref. 9). Additional domains and insertions in extant aaRSs (in red and blue) were added later, perhaps to increase the specificity of each enzyme for its cognate tRNAs through new molecular interactions13. This process (depicted by dashed arrows) gave rise to the extant forms of aminoacyl-tRNA synthetases. At any stage of this evolutionary process, single domains, or combinations of them, can have diverged (solid arrows) to generate the extant aaARS-like proteins, represented in the box to the right of the figure.