12β-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata
12β-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata
复制标题
12 β-乙酰氧基穿孔素，一种来自 Harrisonia Perforata 的新柠檬苦素类化合物
DOI：
10.1080/14786419.2018.1508139
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发表时间：
2019-10-02
影响因子：
2.2
通讯作者：
Hao, Xiao-Jiang
中科院分区：
文献类型：
--
作者：
Gui, Peng-Yan;Yan, Xiao-Hui;Hao, Xiao-Jiang
从花楸叶中分离出一种新的A， D-seco类柠檬素，命名为12-乙酰氧基穿孔素（12-acetyloxyperforatin, 1）。它们的结构是在光谱分析的基础上阐明的，包括广泛的核磁共振技术和计算模型。这些化合物对11 β - hsd1酶无抑制活性。
A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11 beta-HSD1 enzyme.