Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience
Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience
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DOI：
10.1002/hed.24355
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Zafereo, Mark E.
中科院分区：
文献类型：
--
作者：
Sandulache, Vlad C.;Vandelaar, Laura J.;Zafereo, Mark E.
背景。本研究的目的是评估挽救性全喉切除术（STL）后的临床和功能结果。我们对1994年至2014年间接受STL的218例患者进行了回顾性分析。70%的患者最初患有T1或T2，无肿瘤，73%的患者单独接受了明确的外束放疗（EBRT）。在最后一次随访中，大多数患者使用了气管食管假体（77%），并无胃造口术（80%）。5年疾病控制率为65%，总生存率为57%。患者初始治疗后无病间期为5年，无病间期为60%
Background. The purpose of this study was to present our evaluation of the clinical and functional outcomes after salvage total laryngectomy (STL).Methods. We conducted a retrospective review of 218 patients who underwent STL between 1994 and 2014.Results. Seventy percent of patients originally had T1 or T2, N0 tumors and 73% had definitive external-beam radiotherapy (EBRT) alone. A majority utilized tracheoesophageal prosthesis (77%) and were gastrostomy free (80%) at last follow-up. The 5-year disease control and overall survival (OS) rates were 65% and 57%, respectively. Patients with a disease-free interval after initial treatment 5-year disease-free interval and 60% for