The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
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DOI：
10.1016/s0092-8674(00)00216-6
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发表时间：
2000-12-22
期刊：
影响因子：
64.5
通讯作者：
Ramakrishnan, V
中科院分区：
文献类型：
--
作者：
Brodersen, DE;Clemons, WM;Ramakrishnan, V
我们利用最近测定的30 S核糖体亚基的原子结构来确定它与抗生素四环素、帕他霉素和潮霉素B的复合物的结构。抗生素与30S亚基上的离散位点结合的方式与大多数但不是所有的生化数据一致。对于这些抗生素中的每一种，与30S亚基的相互作用表明其对核糖体功能的影响机制。
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.