Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas
Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas
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DOI：
10.1002/path.1060
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发表时间：
2002-04-01
影响因子：
7.3
通讯作者：
Koukourakis, MI
中科院分区：
文献类型：
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作者：
Sivridis, E;Giatromanolaki, A;Koukourakis, MI
血管内皮生长因子（VEGF）和胸苷磷酸化酶（TP）是重要的血管生成酶，在许多人类恶性肿瘤中诱导新血管形成。在这项研究中，这两种分子的免疫组化表达进行了分析，在一系列的121个子宫内膜癌。VEGF仅在癌细胞中表达，而TP表达在成纤维细胞和子宫肌层起源的癌细胞（TPcc）和基质细胞（TPsc）中。在所有情况下，酶检测是特别明显的入侵道岔前。在这个部位，TPsc而不是VEGF的表达与非类胶质瘤型癌、高肿瘤分级、深肌层浸润和晚期相关。VEGF，而不是TP，表达与血管生成增加有关（p = 0.01）。然而，两个因素的双重分层将VEGF/TPsc共表达标记为最有效的血管生成表型（p=0.008），表明协同作用。生存分析显示，VEGF和TPsc，无论是单独表达或组合，定义预后不良。然而，在多变量分析中，疾病分期（p
Vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) are important angiogenic enzymes, inducing new blood vessel formation in many human malignancies. In this study, the immunohistochemical expression of the two molecules was analysed in a series of 121 endometrial carcinomas. VEGF was expressed exclusively in cancer cells, while TP expression was shown in cancer cells (TPcc) and in stromal cells (TPsc) of both fibroblastic and myometrial origin. In all cases, enzymatic detection was particularly evident at the invading turnout front. At this site, TPsc, but not VEGF, expression was associated with non-endometrioid-type carcinomas, high tumour grade, deep myometrial invasion, and advanced stage. VEGF, but not TP, expression was related to increased angiogenesis (p = 0.01). Double stratification of the two factors, however, marked VEGF/TPsc co-expression as the most potent angiogenic phenotype (p=0.008), suggesting a synergistic function. Survival analysis revealed that VEGF and TPsc, whether expressed alone or in combination, define poor prognosis. In multivariate analysis, however, stage of disease (p