Sleep-promoting effects of melatonin: At what dose, in whom, under what conditions, and by what mechanisms?
Sleep-promoting effects of melatonin: At what dose, in whom, under what conditions, and by what mechanisms?
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DOI：
10.1093/sleep/20.10.908
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发表时间：
1997-01-01
期刊：
影响因子：
5.6
通讯作者：
Lewy, AJ
中科院分区：
文献类型：
--
作者：
Sack, RL;Hughes, RJ;Lewy, AJ
关于褪黑素促进睡眠作用的不同结论可能是由于使用的剂量范围广泛(0.1-2000毫克)、不同类别的受试者(正常受试者、失眠症患者、老年人等)以及不同的给药时间(白天与夜间睡眠)的结果。我们得出结论，褪黑素可能通过纠正昼夜节律异常和/或通过温和的直接催眠作用而有益于睡眠，这种作用在白天给年轻受试者后最为明显。我们推测，这些效应是通过与集中在视交叉上核(SCN)的特定受体的相互作用而介导的，这些受体导致昼夜节律起搏器的重置和/或依赖于SCN的昼夜节律警报过程的减弱。
Differing conclusions regarding the sleep-promoting effects of melatonin may be the result of the broad range of doses employed (0.1-2000 mg), the differing categories of subjects tested (normal subjects, insomniac patients, elderly, etc.), and the varying times of administration (for daytime vs. nighttime sleep). We conclude that melatonin may benefit sleep by correcting circadian phase abnormalities and/or by a modest direct soporific effect that is most evident following daytime administration to younger subjects. We speculate that these effects are mediated by interactions with specific receptors concentrated in the suprachiasmatic nucleus (SCN) that result in resetting of the circadian pacemaker and/or attenuation of an SCN-dependent circadian alerting process.