FEMININE SEXUAL-BEHAVIOR IN RATS ENHANCED BY PRENATAL INHIBITION OF ANDROGEN AROMATIZATION
FEMININE SEXUAL-BEHAVIOR IN RATS ENHANCED BY PRENATAL INHIBITION OF ANDROGEN AROMATIZATION
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DOI：
10.1016/0018-506x(78)90048-x
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发表时间：
1978-01-01
影响因子：
3.5
通讯作者：
GLADUE, BA
中科院分区：
文献类型：
--
作者：
CLEMENS, LG;GLADUE, BA
雄性和雌性大鼠在子宫内通过产前注射芳构化抑制剂1，4，6-雄三烯-3，17-二酮(ATD)。成年后，测量卵巢激素对前凸行为的反应。与对照组相比，产前暴露于ATD的男性和女性表现出单独对雌激素和对雌激素+黄体酮的反应增强的前凸行为。出生前，雄激素敏感的性分化阶段可能会发生，在这一阶段，雄性和雌性大鼠通常都会发生脱雌化。雄激素芳构化显然是这种脱雌化的一个重要过程。
Male and female rats were exposed to the aromatization inhibitor 1,4,6-androstatriene-3,17-dione (ATD) in utero via prenatal injections to the pregnant mother. In adulthood, lordosis behavior was measured in response to ovarian hormones. Males and females exposed prenatally to ATD showed enhanced lordosis behavior in response to estrogen alone and in response to estrogen plus progesterone when compared to controls. A prenatal, androgen-sensitive phase of sexual differentiation probably occurs in which defeminization normally occurs in both male and female rats. Androgen aromatization is evidently an important process in this defeminization.