Rapid Synthesis of γ-Arylated Carbonyls Enabled by the Merge of Copper- and Photocatalytic Radical Relay Alkylarylation of Alkenes
Rapid Synthesis of γ-Arylated Carbonyls Enabled by the Merge of Copper- and Photocatalytic Radical Relay Alkylarylation of Alkenes
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DOI：
10.1021/acs.orglett.8b03485
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发表时间：
2019-01-04
期刊：
影响因子：
5.2
通讯作者：
Shu, Wei
中科院分区：
文献类型：
--
作者：
Lv, Xu-Lu;Wang, Cong;Shu, Wei
羰基化合物γ -芳基化的温和而实用的方法的发展是有机合成中一个持续的挑战。羰基化合物的正式γ -芳基化通过自由基接力交叉偶联的-溴羰基前体与硼酸在烯烃存在的报道。这种无导向基团的方案允许在环境条件下快速直接地获得各种γ -芳基化酯、酮和酰胺，具有优异的官能团耐受性。
The development of mild and practical methods for the gamma-arylation of carbonyl compounds is an ongoing challenge in organic synthesis. The first formal gamma-arylation of carbonyl compounds via radical relay cross-coupling of alpha-bromocarbonyl precursors with boronic acids in the presence of alkenes is reported. This directing-group-free protocol allows for the rapid and straightforward access to a wide range of gamma-arylated esters, ketones, and amides under ambient conditions with excellent functional group tolerance.