Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma.
Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma.
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P21WAF1/CIP1表达的丧失与胃癌中疾病进展相关。
DOI：
10.1038/bjc.1997.276
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发表时间：
1997
影响因子：
8.8
通讯作者：
Sowa, M
中科院分区：
文献类型：
--
作者：
Ogawa, M;Maeda, K;Onoda, N;Chung, Y S;Sowa, M
先前的研究表明，肿瘤抑制基因在实体瘤的发展中起着重要作用。最近，p21WAF1/CIP1肿瘤抑制蛋白被报道为p53的关键下游效应物和细胞周期蛋白依赖性激酶的有效抑制剂。因此，p21WAF1/CIP1基因被认为在肿瘤抑制中起核心作用。在这项研究中，我们研究了p21蛋白在胃癌中的表达。对172例原发性胃癌标本进行p21蛋白的免疫组织化学染色。检测p21表达与临床病理特征的相关性。172个肿瘤组织中有104个（60.4%）出现p21表达缺失，p21表达缺失的频率随着分期的进展而增加。与无转移的患者相比，淋巴结、肝脏或腹膜转移患者的原发肿瘤中p21的表达经常缺失。在p21阴性肿瘤患者中，治愈性手术后复发的风险明显高于p21阳性肿瘤患者，预后明显差于p21阳性肿瘤患者。原发性胃癌中p21表达的缺失与疾病进展相关。p21基因表达状况可能对本病有预后价值。
Previous studies have shown that tumour-suppressor genes play an important role in the progression of solid tumours. Recently, the p21WAF1/CIP1 tumour-suppressor protein has been reported to work as a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21WAF1/CIP1 gene is thought to play a central role in tumour suppression. In this study we investigated p21 protein expression in gastric carcinomas. A total of 172 primary gastric carcinoma specimens were immunohistochemically stained for p21 protein expression. Correlations between p21 expression and clinicopathological features were examined. Loss of p21 expression was observed in 104 of 172 tumour tissues (60.4%), and the frequency of p21 loss increased as the stage progressed. Expression of p21 in the primary tumour was frequently lost in patients with either lymph node, liver or peritoneal metastases as compared with patients without metastases. In patients with p21-negative tumours, the risk of recurrence following curative surgery was significantly higher, and the prognosis was significantly poorer than in patients with p21-positive tumours. Loss of p21 expression in primary gastric carcinoma correlates with disease progression. The status of p21 gene expression may have prognostic value in this disease.