Autophagy and Lipid Metabolism
Autophagy and Lipid Metabolism
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DOI：
10.1007/978-981-15-0602-4_17
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Li, Wei
中科院分区：
文献类型：
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作者：
Khawar, Muhammad Babar;Gao, Hui;Li, Wei
自噬是一种保守的分解代谢过程，将细胞内蛋白质和细胞器递送到溶酶体进行降解和回收。过去几十年的研究表明，自噬参与细胞命运的决定，并在调节细胞能量和营养物质储备方面发挥关键作用。脂滴是生物体内主要的脂质储存形式。LDs的自噬降解过程称为脂肪吞噬或巨脂肪吞噬。噬脂作用不仅是细胞脂质代谢不可或缺的一部分，而且与肥胖、肝脂肪变性、动脉粥样硬化等代谢紊乱密切相关，本文就近年来噬脂作用的分子调控机制及其在各种生物学过程和代谢紊乱中的作用进行综述。
Autophagy is a conserved catabolic process that delivers intracellular proteins and organelles to the lysosome for degradation and recycling. Evidences over the past decades have proved that autophagy participates in cell fate decision and also plays a key role in regulating cellular energy and nutrient stores. Lipid droplets (LDs) are the main lipid storage form in living organisms. The process of autophagic degradation of LDs is referred to lipophagy or macrolipophagy. Lipophagy is not only indispensable for the cellular lipid metabolism but also closely associated with several metabolic disorders such as obesity, hepatic steatosis, atherosclerosis, and so on. Here, we summarize recent progress in understanding the molecular mechanisms of lipophagy regulation and the emerging roles of lipophagy in various biological processes and metabolic disorders.