LINES OF BLASCHKO - REVIEW AND RECONSIDERATION - OBSERVATIONS OF CAUSE OF CERTAIN UNUSUAL LINEAR CONDITIONS OF SKIN
LINES OF BLASCHKO - REVIEW AND RECONSIDERATION - OBSERVATIONS OF CAUSE OF CERTAIN UNUSUAL LINEAR CONDITIONS OF SKIN
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DOI：
10.1111/j.1365-2133.1976.tb00835.x
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发表时间：
1976-01-01
影响因子：
10.3
通讯作者：
JACKSON, R
中科院分区：
文献类型：
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作者：
JACKSON, R
Blaschko线是人类皮肤和粘膜上许多不同的痣样和获得性皮肤病所呈现的图案。它们是75年前由布拉施科描述和绘制的。这些线与其他线性图案如Voight线、Langer线和脊神经的神经支配线相区别。它们不遵循皮肤中任何已知的神经、血管或淋巴结构。表皮及其附属结构、黑素细胞、血管系统和脂肪皮下组织，都可能单独或联合参与遵循Blaschko线的形态学表现。许多痣样皮肤病是终身的（例如，线状皮脂腺痣，单侧痣样毛细血管扩张）;许多获得性皮肤病（例如，条纹状苔藓，线状银屑病）的持续时间相对较短（例如，1-2年）。这种分布模式的原因尚不清楚。它可能是人类嵌合现象的一种形式，其中某些特定的细胞或细胞群由于染色体异常而与其他细胞反应不同。布拉施科品系的胚胎学解释还很不清楚。除了皮肤发现之外，还需要其他标志物来确定造成这些线条的变化的时间和性质。[可能的染色体和胚胎学异常需要进一步研究，以确定它们与品系的联系。
Blaschko''s lines are the pattern assumed by many different nevoid and acquired skin diseases on the human skin and mucosae. They were described and drawn by Blaschko 75 yr ago. These lines are to be distinguished from other linear patterns such as Voight''s lines, Langer''s lines and the lines of innervation of the spinal nerves. They do not follow any known nervous, vascular or lymphatic structures in the skin. The epidermis and its appendageal structures, the melanocytes, the vascular system and the fatty hypoderm, all, separately or in combination, may be involved in the morphological manifestations which follow Blaschko''s lines. Many of the nevoid skin conditions are lifelong (e.g., linear sebaceous nevus, unilateral nevoid telangiectasia); many of the acquired skin diseases (e.g., lichen striatus, linear psoriasis) are of relatively short duration (e.g., 1-2 yr). The cause of the distribution pattern is unknown. It is possibly a form of human mosaicism where certain specific cells or groups of cells react differently from other cells due to chromosomal abnormalities. The embryological explanation of Blaschko''s lines is not at all clear. Other markers in addition to the skin findings are needed to determine the time and the nature of the change responsible for these lines. [Possible chromosomal and embryological abnormalities need further study as to their linkage to the lines.].