In vitro antimycobacterial activities of capuramycin analogues.
In vitro antimycobacterial activities of capuramycin analogues.
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辣椒霉素类似物的体外抗分枝杆菌活性。
DOI：
10.1128/aac.01469-07
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发表时间：
2008
影响因子：
4.9
通讯作者：
Nacy,CarolA
中科院分区：
文献类型：
--
作者：
Reddy,VenkataM;Einck,Leo;Nacy,CarolA
来自卡普霉素的转位酶I抑制剂化合物对几种不同的分枝杆菌表现出快速杀菌活性。SQ 641是活性最强的化合物，MIC为0.12 ~ 8 μg/ml，抗生素后效应为55 h，与其他抗结核药物具有有趣的协同效应。
Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 μg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.