New Mixed Li/Mg and Li/Mg/Zn Amides for the Chemoselective Metallation of Arenes and Heteroarenes
New Mixed Li/Mg and Li/Mg/Zn Amides for the Chemoselective Metallation of Arenes and Heteroarenes
复制标题
DOI：
10.1002/ejoc.200801277
复制
发表时间：
2009-04
影响因子：
2.8
通讯作者：
Christoph J. Rohbogner;S. Wunderlich;G. Clososki;P. Knochel
中科院分区：
文献类型：
--
作者：
Christoph J. Rohbogner;S. Wunderlich;G. Clososki;P. Knochel
从容易制备的仲胺开始，合成了新的混合Li/Mg和Li/Mg/Zn酰胺。它们允许各种多官能芳族化合物和杂芳族化合物的高度化学选择性定向镁化或锌化。这些新碱的动力学碱度，溶解度和稳定性已与相应的2，2，6，6-四甲基哌嗪衍生的碱进行了比较。（© Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2009）
New mixed Li/Mg and Li/Mg/Zn amides have been synthesized starting from readily prepared secondary amines. They allow a highly chemoselective directed magnesiation or zincation of various polyfunctional aromatics and heteroaromatics. The kinetic basicity, solubility and stability of these new bases have been compared with those of the corresponding 2,2,6,6-tetramethylpiperamide-derived bases.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)