Neutrophil chemotactic factors.
Neutrophil chemotactic factors.
复制标题
中性粒细胞趋化因子。
DOI：
10.1007/springerreference_39254
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
L. Harvath
中科院分区：
文献类型：
--
作者：
L. Harvath
多态性白细胞（中性粒细胞）通过各种刺激中性粒细胞定向迁移（趋化性）的可溶性介质（化学引诱物）募集到炎症部位。许多中性粒细胞化学引诱物，如中性粒细胞活化蛋白、白三烯B4（LTB 4）、血小板活化因子和补体衍生的C5 a，由宿主细胞或宿主蛋白的酶促裂解内源性产生。其他化学引诱物如N-甲酰肽是由侵入宿主的细菌外源产生的。甲硫氨酸残基的氧化修饰或肽化学引诱物的氨基酸序列的变化显著地改变其化学吸引特性。许多定义明确的中性粒细胞趋化因子和它们的结构与功能关系的研究将被审查。
Polymorphonuclear leukocytes (neutrophils) are recruited to inflammatory sites by a variety of soluble mediators (chemoattractants) that stimulate neutrophil directed migration (chemotaxis). Many neutrophil chemoattractants such as neutrophil activating proteins, leukotriene B4 (LTB4), platelet activating factor, and complement-derived C5a, are generated endogenously by host cells or enzymatic cleavage of host proteins. Other chemoattractants such as N-formyl peptides are generated exogenously by bacteria that invade the host. Oxidative modification of methionine residues or changes in the amino acid sequence of peptide chemoattractants dramatically alter their chemoattractive properties. Many of the well-defined neutrophil chemotactic factors and studies of their structure-function relationships will be reviewed.