C60 IN MODEL BIOLOGICAL-SYSTEMS - A VISIBLE-UV ABSORPTION STUDY OF SOLVENT-DEPENDENT PARAMETERS AND SOLUTE AGGREGATION
C60 IN MODEL BIOLOGICAL-SYSTEMS - A VISIBLE-UV ABSORPTION STUDY OF SOLVENT-DEPENDENT PARAMETERS AND SOLUTE AGGREGATION
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DOI：
10.1021/j100064a035
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发表时间：
1994-03-31
影响因子：
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通讯作者：
SETA, P
中科院分区：
文献类型：
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作者：
BENSASSON, RV;BIENVENUE, E;SETA, P
对C60在各种溶剂和生物学感兴趣的系统中的增溶进行了研究，即，辛醇，胶束和脂质体，使用可见-紫外吸收光谱作为诊断工具。在胶束和胶体脂质体溶液中的C60分子的掺入的状态进行了监测，使用一些光谱标准的溶质-溶剂和溶质-溶质的相互作用的基础上得到的光谱在烷烃和辛醇溶剂和薄膜的C60的比较。光谱红移和强度修改的C60吸收和C60聚集的环境依赖的物理参数进行了讨论。结果表明，C_（60）在Triton X-100和Triton X- 100 R-S胶束溶液中分散良好，富勒烯分子位于胶束的内疏水区。C60被证明是纳入，主要是作为聚集体，磷脂酰胆碱脂质体胶体溶液。可以得出结论，可以制备胶束和脂质体溶液，其可用于将单个C60分子或分子组转移到生物细胞中。
A study was made of the solubilization of C60 in various solvents and systems of biological interest, i.e., octanols, micelles, and liposomes, using visible-UV absorption spectroscopy as a diagnostic tool. The state of incorporation of C60 molecules in micellar and colloidal liposome solutions was monitored using a number of spectroscopic criteria of solute-solvent and solute-solute interactions based on comparison with spectra obtained in alkane and octanol solvents and from thin films of C60. Spectral red shifts and intensity modifications of C60 absorption and C60 aggregation are discussed in terms of environment-dependent physical parameters. The results indicate that C60 can be dispersed in micellar solutions of Triton X-100 and Triton X- 100 R-S, the fullerene molecules being localized in the inner hydrophobic part of the micelles. C60 was shown to be incorporated, mainly as aggregates, into phosphatidylcholine liposome colloidal solutions. It is concluded that micellar and liposome solutions can be prepared which could be used to transfer individual C60 molecules, or groups of molecules, to biological cells.