Plasma Leptin and Reduced FEV(1) and FVC in Chronic Spinal Cord Injury.
Plasma Leptin and Reduced FEV(1) and FVC in Chronic Spinal Cord Injury.
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DOI：
10.1016/j.pmrj.2017.08.437
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Hart JE
中科院分区：
文献类型：
--
作者：
Garshick E;Walia P;Goldstein RL;Teylan M;Lazzari AA;Tun CG;Hart JE
脂肪组织产生促炎症的瘦素和具有抗炎特性的脂联素。患有慢性脊髓损伤(SCI)的参与者体脂增加，患呼吸系统疾病的风险增加。评估慢性脊髓损伤队列中瘦素和脂联素与肺功能的关系。横断面研究。退伍军人事务医疗中心。来自波士顿退伍军人管理局和社区的285名慢性脊髓损伤患者(237名男性和48名女性)，平均损伤持续时间为17.8(13.2)年，参与了一项评估与呼吸健康相关的因素的流行病学研究。参与者(24.6%的颈椎AISA、B和C；33.6%的其他AISA、B和C；41.8%的AISD)提供血样，完成呼吸健康问卷，并接受肺活量测定。使用线性回归方法评估血浆瘦素和脂联素之间的横断面相关性，肺功能的肺活量测量根据年龄、种族、性别和身高进行调整。脊髓损伤的程度和严重程度、活动方式、体重指数、吸烟、COPD、哮喘、胸部损伤史、实验室批次和其他潜在的混杂因素也被考虑在内。FEV1、FVC和FEV1/FVC。血浆瘦素与FEV1和FVC呈显著负相关(以四分位为单位或作为连续协变量)。在完全调整的模型中，瘦素的每四分位数范围(16,214 pg/ml)增加与FEV1显著降低(−93.1ml；95%CI：−166.2，−20.0)和FVC降低(−130.7 ml；95%CI：−219.4，−42.0)相关。瘦素与FEV1/FVC或血浆脂联素与FEV1、FVC或FEV1/FVC之间无显著相关性。慢性脊髓损伤患者血浆瘦素水平与FEV1、FVC呈负相关，与脊髓损伤程度、严重程度及其他协变量无关。这一发现提示血浆瘦素可能是慢性脊髓损伤患者肺功能下降的原因之一。II级
Adipose tissue produces leptin, which is pro-inflammatory, and adiponectin, which has anti-inflammatory properties. Participants with chronic spinal cord injury (SCI) have increased body fat and are at increased risk for respiratory illness. To assess associations between leptin and adiponectin with pulmonary function in a chronic SCI cohort. Cross-sectional study. Veterans Affairs Medical Center. 285 participants (237 men and 48 women) with chronic SCI with mean (sd) injury duration 17.8 (13.2) years from VA Boston and the community participating in an epidemiologic study assessing factors associated with respiratory health. Participants (24.6% Cervical AIS A, B, and C; 33.6% other AIS A, B, and C; 41.8% AIS D) provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry. Linear regression methods were used to assess cross-sectional associations between plasma leptin and adiponectin with spirometric measures of pulmonary function adjusted for age, race, sex, and height. Level and severity of SCI, mobility mode, BMI, smoking, COPD, asthma, chest injury history, laboratory batch, and other potential confounders were also considered. FEV1, FVC, and FEV1/FVC. There was a statistically significant inverse relationship between plasma leptin assessed in quartiles or as a continuous covariate with FEV1 and FVC. In fully adjusted models, each interquartile range (16,214 pg/mL) increase in leptin was associated with a significant decrease in FEV1 (−93.1 ml; 95%CI: −166.2, −20.0) and decrease in FVC (−130.7 ml; 95%CI: −219.4, −42.0). There were no significant associations between leptin and FEV1/FVC or between plasma adiponectin with FEV1, FVC, or FEV1/FVC. Plasma leptin in individuals with chronic SCI is inversely associated with FEV1, and FVC, independently of SCI level and severity and other covariates. This finding suggests that plasma leptin may contribute to reduced pulmonary function in chronic SCI. Level II
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DOI：
10.4168/aair.2014.6.3.189
发表时间：
2014-05
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Kim SH;Sutherland ER;Gelfand EW
通讯作者：
Gelfand EW
DOI：
10.1016/j.apmr.2006.06.015
发表时间：
2006-10-01
影响因子：
4.3
作者：
Jain, Nitin B.;Brown, Robert;Garshick, Eric
通讯作者：
Garshick, Eric
影响因子：
5
作者：
Holguin, Fernando;Rojas, Mauricio;Hart, C. Michael
通讯作者：
Hart, C. Michael
影响因子：
8.3
作者：
Oh, Yeon-Mok;Jeong, Byeong-Ho;Park, Hye Yun
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Park, Hye Yun
影响因子：
1.7
作者：
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通讯作者：
Krassioukov, Andrei