Lipidome determinants of maximal lifespan in mammals.
Lipidome determinants of maximal lifespan in mammals.
复制标题
哺乳动物最大寿命的脂质组决定因素
DOI：
10.1038/s41598-017-00037-7
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发表时间：
2017-01-31
影响因子：
4.6
通讯作者：
Khaitovich P
中科院分区：
文献类型：
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作者：
Bozek K;Khrameeva EE;Reznick J;Omerbašić D;Bennett NC;Lewin GR;Azpurua J;Gorbunova V;Seluanov A;Regnard P;Wanert F;Marchal J;Pifferi F;Aujard F;Liu Z;Shi P;Pääbo S;Schroeder F;Willmitzer L;Giavalisco P;Khaitovich P
哺乳动物物种的最长寿命，即使是密切相关的，也可能相差10倍以上，然而，决定这种差异的机制的本质尚不清楚。在这里，我们评估了最大寿命与超过20,000种脂质化合物浓度之间的关系，测量了来自35个物种的6个组织的669个组织样本，代表了三个哺乳动物分支：灵长类动物、啮齿动物和蝙蝠。我们在三个进化支中发现了与物种寿命相关的脂质，这些脂质与其他参数（如基础代谢率、体型或体温）不耦合。这些脂质聚集在特定的脂质类别和途径中，与它们相关的酶在长寿物种中显示出更大的稳定选择特征，并聚集在与信号传导和蛋白质修饰过程相关的功能群中。这些发现表明哺乳动物最大寿命差异存在明确的分子机制。
Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.