Newborn hearing screening: Will children with hearing loss caused by congenital cytomegalovirus infection be missed?
Newborn hearing screening: Will children with hearing loss caused by congenital cytomegalovirus infection be missed?
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DOI：
10.1016/s0022-3476(99)70328-8
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发表时间：
1999-07-01
影响因子：
5.1
通讯作者：
Pass, RF
中科院分区：
文献类型：
--
作者：
Fowler, KB;Dahle, AJ;Pass, RF
目标：为了预测通用新生儿听力筛查Mill是否能识别出大多数先天性巨细胞病毒（CMV）感染引起的感音神经性听力损失（SNHL）的婴儿，研究设计：在一家医院出生于1980年至1996年的388名儿童的队列，在新生儿期间被确定为先天性CMV感染，接受重复的听力评估，以评估是否发生了听力损失。SNHL在所有婴儿出生时检测到5.2%。晚发性SNHL发生在儿童的前6年。截至72个月龄，该队列SNHL的累积发生率为15.4%。出生时有明显临床疾病的儿童比无任何明显疾病的儿童有更多的SNHL（3个月时22.8%比4.0%，72个月时36.4%比11.3%）。结论：新生儿听力筛查将发现不到一半的先天性CMV感染引起的SNHL。由于大多数先天性CMV感染的婴儿在出生时没有症状，这些儿童不太可能被认为有SNHL的风险，也不会接受进一步的听力评估来检测迟发性听力损失。需要考虑对新生儿进行听力和先天性巨细胞病毒感染的综合筛查。
Objective: To predict whether universal newborn auditory screening Mill identify most infants with sensorineural hearing loss (SNHL) caused by congenital cytomegalovirus (CMV) infection.Study design: A cohort of 388 children born between 1980 and 1996 at one hospital and identified during the newborn period as having congenital CMV infection received repeated hearing evaluations to assess whether hearing loss had occurred.Results: SNHL was detected in 5.2% of all infants at birth. Late-onset SNHL occurred among the children throughout the first 6 years of life. BS the age of 72 months, the cumulative incidence of SNHL was 15.4% in the cohort. Children with clinically apparent disease at birth had significantly more SNHL than children without any apparent disease (22.8% vs 4.0% at 3 months and 36.4% vs 11.3% at 72 months of age).Conclusions: Universal screening of hearing in neonates will detect less than half of all SNHL caused by congenital CMV infection. Because most infants with congenital CMV infection are without symptoms at birth, ;these children are unlikely to be recognized as being at risk for SNHL and will not receive further hearing evaluations to detect late-onset hearing loss. A combined approach of universal screening of neonates for hearing, as well as for detection of congenital CMV infection, needs to be considered.