CEREBRAL BLOOD-FLOW AND CEREBRAL METABOLIC-RATE OF OXYGEN REQUIREMENTS FOR CEREBRAL FUNCTION AND VIABILITY IN HUMANS
CEREBRAL BLOOD-FLOW AND CEREBRAL METABOLIC-RATE OF OXYGEN REQUIREMENTS FOR CEREBRAL FUNCTION AND VIABILITY IN HUMANS
复制标题
DOI：
10.1038/jcbfm.1985.89
复制
发表时间：
1985-01-01
影响因子：
6.3
通讯作者：
RAICHLE, ME
中科院分区：
文献类型：
--
作者：
POWERS, WJ;GRUBB, RL;RAICHLE, ME
本研究旨在确定人类大脑维持正常功能和活力超过几个小时所需的最小CBF和cmor2。采用正电子发射断层扫描（PET）对50例不同程度脑缺血但无梗死迹象的受试者进行局部测量。24名正常受试者，24名有颈动脉系统血管疾病的动脉造影证据的受试者，2名因脑血管痉挛而出现可逆性缺血性神经功能缺损的受试者。48例神经功能正常受试者的最小值为区域脑血流量（rCBF） 19 ml/100 g-min，区域脑氧代谢率（rcro2） 1.3 ml/100 g-min。在所有50例脑组织存活的受试者中，rCBF的最小值为15 ml/100 g-min， rcmor2的最小值为1.3 ml/100 g-min。将这些测量值与10名受试者的20个脑梗死区域的测量值进行比较，表明80%（16/20）的梗死区域的rcro2值低于正常下限1.3 m/100 g-min。rCBF、局部脑血容量和氧提取分数的测量对于区分活组织和梗死组织的作用较小。这些数据表明，PET定量区域测量可准确区分活脑组织和非活脑组织，并可用于可逆性缺血患者的前瞻性识别。
This study was undertaken to determine the minimum CBF and CMRO2 required by the human brain to maintain normal function and viability for more than a few hours. Positron emission tomography (PET) was used to perform regional measurements in 50 subjects with varying degrees of cerebral ischemia but no evidence of infarction. There were 24 normal subjects, 24 subjects with arteriographic evidence of vascular disease of the carotid system, and two subjects with reversible ischemic neurological deficits due to cerebral vasospasm. Minimum values found in the 48 subjects with normal neurological function were 19 ml/100 g-min for regional cerebral blood flow (rCBF) and 1.3 ml/100 g-min for regional cerebral metabolic rate of oxygen (rCMRO2). Minimum values for all 50 subjects with viable cerebral tissue were 15 ml/100 g-min for rCBF and 1.3 ml/100 g-min for rCMRO2. Comparison of these measurements with values from 20 areas of established cerebral infarction in 10 subjects demonstrated that 80% (16/20) of infarcted regions had rCMRO2 values below the lower normal limit of 1.3 m/100 g-min. Measurements of rCBF, regional cerebral blood volume, and oxygen extraction fraction were less useful for distinguishing viable from infarcted tissue. These data indicate that quantitative regional measurements of rCMRO2 with PET accurately distinguish viable from nonviable cerebral tissue and may be useful in the prospective identification of patients with reversible ischemia.