Interactive influence of sex, stressor timing, and the BclI glucocorticoid receptor polymorphism on stress-induced alterations of long-term memory.
Interactive influence of sex, stressor timing, and the BclI glucocorticoid receptor polymorphism on stress-induced alterations of long-term memory.
复制标题
性别、压力源时间和 BclI 糖皮质激素受体多态性对压力引起的长期记忆改变的交互影响。
DOI：
10.1016/j.bandc.2018.05.012
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发表时间：
2019
影响因子：
2.5
通讯作者：
Dailey,AlisonM
中科院分区：
文献类型：
--
作者：
Zoladz,PhillipR;Duffy,TessaJ;Mosley,BrianneE;Fiely,MirandaK;Nagle,HannahE;Scharf,AmandaR;Brown,CallieM;Earley,McKennaB;Rorabaugh,BoydR;Dailey,AlisonM
某些易感因素，如遗传变异或对压力的特定生理反应，可以决定压力对学习和记忆的影响。在这里，我们研究了糖皮质激素受体基因的BclI多态性对学习前应激对长时记忆的时间依赖性影响的影响。健康人暴露于社会评价冷加压试验或控制条件下立即或30分钟前单词列表学习。参与者对单词的记忆在学习后立即和24小时进行测试，并收集唾液样本，对参与者进行Bcl I多态性基因型分析，并评估皮质醇对压力源的反应。结果显示，学习前的压力增强记忆，而学习前30分钟的压力损害记忆，这些影响在很大程度上是选择性的男性和非唤起的话。此外，压力，独立于当它被管理，增强记忆在非运营商的theBclI多态性，而损害记忆的运营商，这些影响在很大程度上是选择性的男性和参与者表现出强大的皮质醇应激反应。这些结果为压力对长期记忆的时间依赖性影响提供了进一步的证据，并表明BclI多态性的携带者可能对皮质类固醇对学习的负面影响更敏感。
Certain susceptibility factors, such as genetic variants or specific physiological responses to stress, can dictate the effects of stress on learning and memory. Here, we examined the influence of theBclI polymorphism of the glucocorticoid receptor gene on the time-dependent effects of pre-learning stress on long-term memory. Healthy individuals were exposed to the socially evaluated cold pressor test or a control condition immediately or 30 min before word list learning. Participants’ memory for the words was tested immediately and 24 h after learning, and saliva samples were collected to genotype participants for theBclI polymorphism and to assess cortisol responses to the stressor. Results revealed that stress immediately before learning enhanced memory, while stress 30 min before learning impaired memory; these effects were largely selective to males and non-arousing words. Additionally, stress, independent of when it was administered, enhanced memory in non-carriers of theBclI polymorphism, while impairing memory in carriers; these effects were largely selective to males and participants exhibiting a robust cortisol response to stress. These results provide further evidence for time-dependent effects of stress on long-term memory and suggest that carriers of theBclI polymorphism might be more sensitive to the negative effects of corticosteroids on learning.