DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection
DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection
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DOI：
10.1086/522609
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发表时间：
2007-11-15
影响因子：
6.4
通讯作者：
Katz, Jacqueline M.
中科院分区：
文献类型：
--
作者：
Belser, Jessica A.;Lu, Xiuhua;Katz, Jacqueline M.
Increasing resistance to currently available influenza antivirals highlights the need to develop alternate approaches for the prevention and/or treatment of influenza. DAS181 (Fludase), a novel sialidase fusion protein that enzymatically removes sialic acids on respiratory epithelium, exhibits potent antiviral activity against influenzaA and B viruses. Here, we use a mouse model to evaluate the efficacy of DAS181 treatment against a highly pathogenic avian influenzaH5N1virus. When used to treat mice daily beginning 1 day before infection with A/Vietnam/1203/2004(H5N1) virus, DAS181 treatment at 1 mg/kg/day protected 100% of mice from fatal disease, prevented viral dissemination to the brain, and effectively blocked infection in 70% of mice. DAS181 at 1 mg/kg/day was also effective therapeutically, conferring enhanced survival of H5N1 virus-challenged mice when treatment was begun 72 h after infection. This notable antiviral activity underscores the potential utility of DAS181 as a new class of drug that is effective against influenza viruses with pandemic potential.
